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    Tle4 transducin-like enhancer of split 4 [ Mus musculus (house mouse) ]

    Gene ID: 21888, updated on 18-Sep-2021

    Summary

    Official Symbol
    Tle4provided by MGI
    Official Full Name
    transducin-like enhancer of split 4provided by MGI
    Primary source
    MGI:MGI:104633
    See related
    Ensembl:ENSMUSG00000024642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grg; Bce1; Grg4; Bce-1; ESTM1; grg-4; ESTM13; ESTM14; X83332; X83333; AA792082; 5730411M05Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 15.3), CNS E18 (RPKM 14.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tle4 in Genome Data Viewer
    Location:
    19 A; 19 9.11 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (14425436..14575547, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (14448072..14598183, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (14522562..14672473, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor enhancer Tinos Neighboring gene predicted gene, 31331 Neighboring gene predicted gene 8630 Neighboring gene predicted gene, 31441 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene ribosomal protein L13 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transducin-like enhancer protein 4
    Names
    B lymphocyte gene 1
    groucho-related protein 4
    transducin-like enhancer of split 4, homolog of Drosophila E(spl)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302947.1NP_001289876.1  transducin-like enhancer protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001289876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122202, AC125315, AK134989, BB065515, BC086780, CX238105
      UniProtKB/TrEMBL
      Q3UY41
      Conserved Domains (3) summary
      cd00200
      Location:487771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:491530
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:16139
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    2. NM_001302950.1NP_001289879.1  transducin-like enhancer protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001289879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC122202, AC125315, AK134989, BB065515, BC086780, CX238105
      UniProtKB/TrEMBL
      Q3UY41
      Conserved Domains (3) summary
      cd00200
      Location:462746
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:466505
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:16103
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    3. NM_001302951.1NP_001289880.1  transducin-like enhancer protein 4 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5'-terminal exon, which results in a distinct 5' UTR and use of an alternate start codon, compared to variant 1. The encoded protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC122202, AC125315, AK134989, BB065515, BC086780, BQ769921, BY073734
      UniProtKB/TrEMBL
      Q3UY41
      Conserved Domains (3) summary
      cd00200
      Location:485769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:489528
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:14137
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    4. NM_011600.3NP_035730.2  transducin-like enhancer protein 4 isoform 2

      See identical proteins and their annotated locations for NP_035730.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter by one amino acid compared to isoform 1.
      Source sequence(s)
      AC122202, AC125315, AK134989, BB065515, BC086780, CX238105
      Consensus CDS
      CCDS50399.1
      UniProtKB/Swiss-Prot
      Q62441
      UniProtKB/TrEMBL
      Q3UY41
      Related
      ENSMUSP00000057527.8, ENSMUST00000052011.15
      Conserved Domains (3) summary
      cd00200
      Location:486770
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:490529
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:16138
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      14425436..14575547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526913.2XP_006526976.1  transducin-like enhancer protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006526976.1

      Conserved Domains (3) summary
      cd00200
      Location:461745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:465504
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:8113
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    2. XM_030250862.2XP_030106722.1  transducin-like enhancer protein 4 isoform X1

      Conserved Domains (3) summary
      cd00200
      Location:484768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:488527
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:14136
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    3. XM_030250864.2XP_030106724.1  transducin-like enhancer protein 4 isoform X4

      Conserved Domains (3) summary
      cd00200
      Location:459743
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:463502
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:14107
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    4. XM_030250863.2XP_030106723.1  transducin-like enhancer protein 4 isoform X3

      Conserved Domains (3) summary
      cd00200
      Location:460744
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:464503
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:14101
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    5. XM_006526914.5XP_006526977.1  transducin-like enhancer protein 4 isoform X5

      Conserved Domains (3) summary
      cd00200
      Location:366650
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:370409
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:118
      TLE_N; Groucho/TLE N-terminal Q-rich domain
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