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    Atp6v0a2 ATPase, H+ transporting, lysosomal V0 subunit A2 [ Mus musculus (house mouse) ]

    Gene ID: 21871, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atp6v0a2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit A2provided by MGI
    Primary source
    MGI:MGI:104855
    See related
    Ensembl:ENSMUSG00000038023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATP; ISF; Tj6; J6B7; SHIF; Stv1; TJ6M; TJ6s; ATP6a2; Atp6n2; C76904; Atp6n1d; AI385560; AW489264; V-ATPase a2; 8430408C20Rik; V-ATPase 116 kDa
    Summary
    This gene encodes a subunit of vacuolar ATPase, a multimeric enzyme that localizes to intracellular vesicles and to the plasma membrane of specialized cells. The encoded protein is a component of the V(0) domain, which functions in proton translocation across membranes. Function of this gene is important in fetal-specific immune suppression during pregnancy. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 48.7), duodenum adult (RPKM 33.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atp6v0a2 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124767117..124801519)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124629052..124724455)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125079648..125097437) , (125192573..125202524)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene tectonic family member 2 Neighboring gene dynein, axonemal, heavy chain 10 Neighboring gene coiled-coil domain containing 92

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124341, MGC124342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase 116 kDa subunit a2
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)
    ATPase, H+ transporting, lysosomal V0 subunit a
    T-cell expressing clone j6
    V-ATPase 116 kDa subunit a2
    V-type proton ATPase 116 kDa subunit a
    immune suppressor factor J6B7
    vacuolar proton translocating ATPase 116 kDa subunit a
    NP_035726.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011596.5NP_035726.2  V-type proton ATPase 116 kDa subunit a2

      See identical proteins and their annotated locations for NP_035726.2

      Status: REVIEWED

      Source sequence(s)
      AF218252, AK017467, AK032909, AK160318, BP764071, CJ076040
      Consensus CDS
      CCDS84963.1
      UniProtKB/Swiss-Prot
      P15920
      Related
      ENSMUSP00000039737.9, ENSMUST00000037865.13
      Conserved Domains (2) summary
      COG1269
      Location:5839
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28839
      V_ATPase_I; V-type ATPase 116kDa subunit family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      124767117..124801519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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