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    Atp6v0a2 ATPase, H+ transporting, lysosomal V0 subunit A2 [ Mus musculus (house mouse) ]

    Gene ID: 21871, updated on 3-Feb-2019

    Summary

    Official Symbol
    Atp6v0a2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit A2provided by MGI
    Primary source
    MGI:MGI:104855
    See related
    Ensembl:ENSMUSG00000038023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ISF; Tj6; J6B7; SHIF; Stv1; TJ6M; TJ6s; ATP6a2; Atp6n2; C76904; Atp6n1d; AI385560; AW489264; V-ATPase a2; 8430408C20Rik; V-ATPase 116 kDa
    Summary
    This gene encodes a subunit of vacuolar ATPase, a multimeric enzyme that localizes to intracellular vesicles and to the plasma membrane of specialized cells. The encoded protein is a component of the V(0) domain, which functions in proton translocation across membranes. Function of this gene is important in fetal-specific immune suppression during pregnancy. [provided by RefSeq, May 2013]
    Annotation information
    Annotation category: spans an assembly gap
    Expression
    Ubiquitous expression in large intestine adult (RPKM 48.7), duodenum adult (RPKM 33.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atp6v0a2 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (124629052..124724455)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125079648..125097437) , (125192573..125202524)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene tectonic family member 2 Neighboring gene dynein, axonemal, heavy chain 10 Neighboring gene coiled-coil domain containing 92

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124341, MGC124342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     
    vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase 116 kDa subunit a isoform 2
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)
    ATPase, H+ transporting, lysosomal V0 subunit a
    T-cell expressing clone j6
    V-type proton ATPase 116 kDa subunit a
    immune suppressor factor J6B7
    vacuolar proton translocating ATPase 116 kDa subunit a
    NP_035726.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011596.5NP_035726.2  V-type proton ATPase 116 kDa subunit a isoform 2

      See identical proteins and their annotated locations for NP_035726.2

      Status: REVIEWED

      Source sequence(s)
      AF218252, AK017467, AK032909, AK160318, BP764071, CJ076040
      Consensus CDS
      CCDS84963.1
      UniProtKB/Swiss-Prot
      P15920
      Related
      ENSMUSP00000039737.8, ENSMUST00000037865.12
      Conserved Domains (2) summary
      COG1269
      Location:5839
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28839
      V_ATPase_I; V-type ATPase 116kDa subunit family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      124629052..124724455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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