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    Pxk PX domain containing serine/threonine kinase [ Mus musculus (house mouse) ]

    Gene ID: 218699, updated on 17-Jul-2021

    Summary

    Official Symbol
    Pxkprovided by MGI
    Official Full Name
    PX domain containing serine/threonine kinaseprovided by MGI
    Primary source
    MGI:MGI:1289230
    See related
    Ensembl:ENSMUSG00000033885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MO; Slob; Monaka; D14Ertd813; D14Ertd813e; C230080L11Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 18.0), placenta adult (RPKM 17.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pxk in Genome Data Viewer
    Location:
    14 A1; 14 4.7 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14304656..14371593, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8098180..8165117)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (8930727..8997625)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53823 Neighboring gene pyruvate dehydrogenase (lipoamide) beta Neighboring gene ribosomal protein L13 pseudogene Neighboring gene ribonuclease P 14 subunit Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene abhydrolase domain containing 6 Neighboring gene predicted gene, 30244

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within modulation of chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    PX domain-containing protein kinase-like protein
    Names
    modulator of Na,K-ATPase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360313.1NP_001347242.1  PX domain-containing protein kinase-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK150660, AK153067, AW455875
      Consensus CDS
      CCDS88565.1
      Related
      ENSMUSP00000035265.9, ENSMUST00000036682.9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186482
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    2. NM_001360314.1NP_001347243.1  PX domain-containing protein kinase-like protein short isoform

      Status: VALIDATED

      Source sequence(s)
      AK150337, AK150660, AK153067, AW455875, CT573024
      Consensus CDS
      CCDS36799.1
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    3. NM_001360315.1NP_001347244.1  PX domain-containing protein kinase-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK150660, AK153067, AW455875, BM945330, CT573024
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186482
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    4. NM_001360316.1NP_001347245.1  PX domain-containing protein kinase-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK150337, AK150660, AK153067, AW455875, CT573024
    5. NM_145458.4NP_663433.2  PX domain-containing protein kinase-like protein long isoform

      See identical proteins and their annotated locations for NP_663433.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (L) encodes the longest isoform.
      Source sequence(s)
      AK150337, AK150660, AK153067, AW455875
      Consensus CDS
      CCDS26810.1
      UniProtKB/Swiss-Prot
      Q8BX57
      Related
      ENSMUSP00000152987.2, ENSMUST00000225653.2
      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    6. NM_178279.3NP_840063.1  PX domain-containing protein kinase-like protein short isoform

      See identical proteins and their annotated locations for NP_840063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (S) uses an alternate splice site in the 3' coding region, compared to variant L. The resulting protein is shorter and has a distinct C-terminus, when compared to the longer isoform.
      Source sequence(s)
      AK150660, AK153067, AW455875, BM945330, CT573024
      Consensus CDS
      CCDS36799.1
      UniProtKB/Swiss-Prot
      Q8BX57
      Related
      ENSMUSP00000108309.3, ENSMUST00000112689.9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      14304656..14371593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517982.3XP_006518045.1  PX domain-containing protein kinase-like protein isoform X7

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    2. XM_006517977.4XP_006518040.1  PX domain-containing protein kinase-like protein isoform X2

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    3. XM_030247724.1XP_030103584.1  PX domain-containing protein kinase-like protein isoform X5

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    4. XM_006517980.3XP_006518043.1  PX domain-containing protein kinase-like protein isoform X6

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    5. XM_006517975.4XP_006518038.1  PX domain-containing protein kinase-like protein isoform X1

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    6. XM_006517978.4XP_006518041.1  PX domain-containing protein kinase-like protein isoform X4

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    7. XM_036158542.1XP_036014435.1  PX domain-containing protein kinase-like protein isoform X9

      Conserved Domains (3) summary
      cd22062
      Location:465495
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    8. XM_036158540.1XP_036014433.1  PX domain-containing protein kinase-like protein isoform X8

      Conserved Domains (3) summary
      cd22062
      Location:466496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    9. XM_036158541.1XP_036014434.1  PX domain-containing protein kinase-like protein isoform X8

      Conserved Domains (3) summary
      cd22062
      Location:466496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    10. XM_030247727.1XP_030103587.1  PX domain-containing protein kinase-like protein isoform X9

      Conserved Domains (3) summary
      cd22062
      Location:465495
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    11. XM_030247728.1XP_030103588.1  PX domain-containing protein kinase-like protein isoform X10

      Conserved Domains (2) summary
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    12. XM_006517984.2XP_006518047.1  PX domain-containing protein kinase-like protein isoform X8

      See identical proteins and their annotated locations for XP_006518047.1

      Conserved Domains (3) summary
      cd22062
      Location:466496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    13. XM_030247726.1XP_030103586.1  PX domain-containing protein kinase-like protein isoform X9

      Conserved Domains (3) summary
      cd22062
      Location:465495
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    14. XM_006517985.2XP_006518048.1  PX domain-containing protein kinase-like protein isoform X8

      See identical proteins and their annotated locations for XP_006518048.1

      Conserved Domains (3) summary
      cd22062
      Location:466496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    15. XM_017315951.2XP_017171440.1  PX domain-containing protein kinase-like protein isoform X6

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    16. XM_017315949.2XP_017171438.1  PX domain-containing protein kinase-like protein isoform X3

      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases

    RNA

    1. XR_874027.3 RNA Sequence

    2. XR_001781106.2 RNA Sequence

    3. XR_004938378.1 RNA Sequence

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