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    Dhx29 DExH-box helicase 29 [ Mus musculus (house mouse) ]

    Gene ID: 218629, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dhx29provided by MGI
    Official Full Name
    DExH-box helicase 29provided by MGI
    Primary source
    MGI:MGI:2145374
    See related
    Ensembl:ENSMUSG00000042426 AllianceGenome:MGI:2145374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddxx; 3732415M03; E130202M19Rik
    Summary
    Predicted to enable several functions, including nucleic acid binding activity; ribonucleoside triphosphate phosphatase activity; and ribosomal small subunit binding activity. Predicted to be involved in formation of translation preinitiation complex and ribosome assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Orthologous to human DHX29 (DExH-box helicase 29). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), CNS E18 (RPKM 5.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Dhx29 in Genome Data Viewer
    Location:
    13 D2.2; 13 63.93 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113063976..113105968)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112927680..112969432)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35701 Neighboring gene predicted gene, 41067 Neighboring gene STARR-seq mESC enhancer starr_35702 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene STARR-positive B cell enhancer ABC_E7290 Neighboring gene STARR-positive B cell enhancer ABC_E1469 Neighboring gene 40S ribosomal protein S13-like Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 
    • Transgenic (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cytosolic small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic 43S preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic 43S preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase Dhx29
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 29
    DEAH box protein 29
    nucleic acid helicase DDXx
    NP_766182.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172594.3NP_766182.2  ATP-dependent RNA helicase Dhx29

      See identical proteins and their annotated locations for NP_766182.2

      Status: VALIDATED

      Source sequence(s)
      AK087450, BC038650, BC057112
      Consensus CDS
      CCDS26779.1
      UniProtKB/Swiss-Prot
      Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9
      Related
      ENSMUSP00000035244.6, ENSMUST00000038574.7
      Conserved Domains (5) summary
      smart00487
      Location:577763
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:10551136
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:588735
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:863984
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:11781298
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      113063976..113105968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938025.1 RNA Sequence