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    Mier3 MIER family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 218613, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mier3provided by MGI
    Official Full Name
    MIER family member 3provided by MGI
    Primary source
    MGI:MGI:2442317
    See related
    Ensembl:ENSMUSG00000032727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU015422; 5730509D14; D130064H19Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mier3 in Genome Data Viewer
    Location:
    13; 13 D2.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111822607..111855130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111686073..111718596)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (112476386..112508802)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15290 Neighboring gene predicted gene 15286 Neighboring gene SET domain containing 9, pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 1 Neighboring gene predicted gene 15327

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117989

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mesoderm induction early response protein 3
    Names
    mesoderm induction early response 1, family member 3
    mi-er3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172593.3NP_766181.2  mesoderm induction early response protein 3

      See identical proteins and their annotated locations for NP_766181.2

      Status: VALIDATED

      Source sequence(s)
      AC118704, AK083929, AK147427
      Consensus CDS
      CCDS26770.2
      UniProtKB/Swiss-Prot
      Q3UHF3
      Related
      ENSMUSP00000104895.3, ENSMUST00000109272.9
      Conserved Domains (3) summary
      smart00717
      Location:281328
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:283327
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176225
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      111822607..111855130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517618.3XP_006517681.1  mesoderm induction early response protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006517681.1

      UniProtKB/TrEMBL
      B9EHL0
      Conserved Domains (2) summary
      cd11661
      Location:256300
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149198
      ELM2; ELM2 domain
    2. XM_030247238.2XP_030103098.1  mesoderm induction early response protein 3 isoform X3

      Related
      ENSMUSP00000104894.3, ENSMUST00000109271.3
      Conserved Domains (2) summary
      cd11661
      Location:282326
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176225
      ELM2; ELM2 domain
    3. XM_006517615.3XP_006517678.1  mesoderm induction early response protein 3 isoform X1

      Conserved Domains (2) summary
      cd11661
      Location:329373
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:222271
      ELM2; ELM2 domain
    4. XM_006517616.3XP_006517679.1  mesoderm induction early response protein 3 isoform X2

      Conserved Domains (2) summary
      cd11661
      Location:328372
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:222271
      ELM2; ELM2 domain
    5. XM_036158025.1XP_036013918.1  mesoderm induction early response protein 3 isoform X4

      Conserved Domains (2) summary
      cd11661
      Location:256300
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149198
      ELM2; ELM2 domain
    6. XM_006517617.1XP_006517680.1  mesoderm induction early response protein 3 isoform X5

      See identical proteins and their annotated locations for XP_006517680.1

      UniProtKB/Swiss-Prot
      Q3UHF3
      Related
      ENSMUSP00000036809.5, ENSMUST00000047412.11
      Conserved Domains (2) summary
      cd11661
      Location:255299
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149198
      ELM2; ELM2 domain

    RNA

    1. XR_382733.3 RNA Sequence

      Related
      ENSMUST00000137268.8
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