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    Srek1 splicing regulatory glutamine/lysine-rich protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 218543, updated on 23-Jun-2021

    Summary

    Official Symbol
    Srek1provided by MGI
    Official Full Name
    splicing regulatory glutamine/lysine-rich protein 1provided by MGI
    Primary source
    MGI:MGI:2145245
    See related
    Ensembl:ENSMUSG00000032621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SR; SRr; Sfr; AL1182; SRrp86; Sfrs12; Srsf12; SRrp508; AI450757; AI462342; 8430401B01
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.3), limb E14.5 (RPKM 7.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Srek1 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (103875119..103911379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (103738565..103774616, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (104531695..104554662, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30551 Neighboring gene predicted gene, 24870 Neighboring gene peptidylprolyl isomerase A pseudogene 13_1282.1 Neighboring gene predicted gene, 52054 Neighboring gene Erbb2 interacting protein Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene predicted gene, 30967 Neighboring gene neurolysin (metallopeptidase M3 family)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    splicing regulatory glutamine/lysine-rich protein 1
    Names
    serine/arginine-rich splicing factor 12
    serine/arginine-rich-splicing regulatory protein 86

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361085.1NP_001348014.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK052265, BC070460
      Consensus CDS
      CCDS88513.1
      Related
      ENSMUSP00000074196.7, ENSMUST00000074616.7
      Conserved Domains (2) summary
      cd12260
      Location:181266
      RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
      cd12519
      Location:2099
      RRM1_SREK1; RNA recognition motif 1 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    2. NM_172592.3NP_766180.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_766180.1

      Status: VALIDATED

      Source sequence(s)
      AK033354, BC070460
      Consensus CDS
      CCDS26743.1
      UniProtKB/Swiss-Prot
      Q8BZX4
      Related
      ENSMUSP00000147737.2, ENSMUST00000210489.2
      Conserved Domains (1) summary
      cd12260
      Location:65150
      RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      103875119..103911379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158024.1XP_036013917.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X5

    2. XM_017315498.3XP_017170987.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X5

    3. XM_006517608.5XP_006517671.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X5

    4. XM_030247237.2XP_030103097.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X3

      Conserved Domains (1) summary
      cd12260
      Location:65150
      RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    5. XM_036158020.1XP_036013913.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X1

      Conserved Domains (2) summary
      cd12260
      Location:181266
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
      cd12519
      Location:2099
      RRM1_SREK1; RNA recognition motif 1 (RRM1) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    6. XM_036158021.1XP_036013914.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

      Conserved Domains (1) summary
      cd12260
      Location:65150
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    7. XM_036158022.1XP_036013915.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X4

    8. XM_006517607.4XP_006517670.2  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

      Conserved Domains (1) summary
      cd12260
      Location:65150
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    9. XM_036158023.1XP_036013916.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X4

    RNA

    1. XR_001780780.3 RNA Sequence

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