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    Rasa1 RAS p21 protein activator 1 [ Mus musculus (house mouse) ]

    Gene ID: 218397, updated on 22-Aug-2021

    Summary

    Official Symbol
    Rasa1provided by MGI
    Official Full Name
    RAS p21 protein activator 1provided by MGI
    Primary source
    MGI:MGI:97860
    See related
    Ensembl:ENSMUSG00000021549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G; Gap; Rasa; p120-; RasGAP
    Expression
    Ubiquitous expression in CNS E14 (RPKM 8.0), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rasa1 in Genome Data Viewer
    Location:
    13 C3; 13 45.05 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (85362818..85437605, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (85214699..85289486, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (85354304..85429091, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NADH-ubiquinone oxidoreductase chain 5-like Neighboring gene cyclin H Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 46396

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7759

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras GTPase-activating protein 1
    Names
    GTPase-activating protein
    p120-rasGAP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145452.3NP_663427.2  ras GTPase-activating protein 1

      Status: VALIDATED

      Source sequence(s)
      BB645489, BC065082, BU055087, CF534745, CV555618
      Consensus CDS
      CCDS26667.2
      UniProtKB/TrEMBL
      E9PYG6
      Related
      ENSMUSP00000105179.3, ENSMUST00000109552.3
      Conserved Domains (8) summary
      cd08400
      Location:582707
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:152255
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:341417
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:272330
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd05391
      Location:7051036
      RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
      smart00323
      Location:6891035
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13260
      Location:480567
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:480568
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      85362818..85437605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244518.4XP_011242820.1  ras GTPase-activating protein 1 isoform X1

      Conserved Domains (6) summary
      cd08400
      Location:582707
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:152255
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:341417
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:272330
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cl02569
      Location:705887
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:480567
      PH-like; Pleckstrin homology-like domain
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