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    Eif4e1b eukaryotic translation initiation factor 4E family member 1B [ Mus musculus (house mouse) ]

    Gene ID: 218268, updated on 22-Aug-2021

    Summary

    Official Symbol
    Eif4e1bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E family member 1Bprovided by MGI
    Primary source
    MGI:MGI:2685119
    See related
    Ensembl:ENSMUSG00000074895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4; Gm273; Eif4eloo
    Expression
    Restricted expression toward ovary adult (RPKM 4.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Eif4e1b in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54931807..54936272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54783994..54788459)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (54885364..54889820)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene synuclein, beta Neighboring gene predicted gene 16249 Neighboring gene tetraspanin 17 Neighboring gene predicted gene, 40959

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E type 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033269.3NP_001028441.1  eukaryotic translation initiation factor 4E type 1B isoform 1

      See identical proteins and their annotated locations for NP_001028441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      DQ279473, DV659735
      Consensus CDS
      CCDS49269.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000123294.2, ENSMUST00000132728.8
      Conserved Domains (1) summary
      pfam01652
      Location:66225
      IF4E; Eukaryotic initiation factor 4E
    2. NM_001039683.2NP_001034772.1  eukaryotic translation initiation factor 4E type 1B isoform 2

      See identical proteins and their annotated locations for NP_001034772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DQ279474, DV659735
      Consensus CDS
      CCDS49270.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000120619.2, ENSMUST00000152204.3
      Conserved Domains (1) summary
      pfam01652
      Location:66161
      IF4E; Eukaryotic initiation factor 4E
    3. NM_001286178.1NP_001273107.1  eukaryotic translation initiation factor 4E type 1B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV653822, DV659735
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000117092.2, ENSMUST00000142158.8
      Conserved Domains (1) summary
      pfam01652
      Location:74230
      IF4E; Eukaryotic initiation factor 4E
    4. NM_001286179.1NP_001273108.1  eukaryotic translation initiation factor 4E type 1B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (4) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV659735, DV662251
      Consensus CDS
      CCDS70460.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      UniProtKB/TrEMBL
      E9PVZ9
      Related
      ENSMUSP00000118697.3, ENSMUST00000126785.8
      Conserved Domains (1) summary
      pfam01652
      Location:75231
      IF4E; Eukaryotic initiation factor 4E
    5. NM_001286180.1NP_001273109.1  eukaryotic translation initiation factor 4E type 1B isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate splice sites in the 5'-terminal exon and in the 3' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (5) has a longer N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV659735, DV662389
      Consensus CDS
      CCDS70459.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      UniProtKB/TrEMBL
      E9Q929
      Related
      ENSMUSP00000116681.2, ENSMUST00000132005.8
      Conserved Domains (1) summary
      pfam01652
      Location:74166
      IF4E; Eukaryotic initiation factor 4E

    RNA

    1. NR_104406.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      DQ279473, DQ279478, DV659735
    2. NR_104407.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two internal exons and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      DQ279473, DQ279479, DV659735

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54931807..54936272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315485.2XP_017170974.1  eukaryotic translation initiation factor 4E type 1B isoform X1

      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000105630.3, ENSMUST00000110003.9
      Conserved Domains (1) summary
      pfam01652
      Location:66225
      IF4E; Eukaryotic initiation factor 4E
    2. XM_017315486.2XP_017170975.1  eukaryotic translation initiation factor 4E type 1B isoform X2

      UniProtKB/Swiss-Prot
      Q3UTA9
      Conserved Domains (1) summary
      pfam01652
      Location:66161
      IF4E; Eukaryotic initiation factor 4E
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