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    Eif4e1b eukaryotic translation initiation factor 4E family member 1B [ Mus musculus (house mouse) ]

    Gene ID: 218268, updated on 18-Nov-2018

    Summary

    Official Symbol
    Eif4e1bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E family member 1Bprovided by MGI
    Primary source
    MGI:MGI:2685119
    See related
    Ensembl:ENSMUSG00000074895 Vega:OTTMUSG00000032677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm273; Eif4eloo
    Expression
    Restricted expression toward ovary adult (RPKM 4.5) See more
    Orthologs

    Genomic context

    See Eif4e1b in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (54783928..54788459)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (54885364..54889820)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene synuclein, beta Neighboring gene predicted gene 16249 Neighboring gene tetraspanin 17 Neighboring gene predicted gene, 40959

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
      PI3K/Akt/mTOR signaling pathway
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • eIF4F complex, organism-specific biosystem (from KEGG)
      eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • eIF4F complex, conserved biosystem (from KEGG)
      eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E type 1B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033269.3NP_001028441.1  eukaryotic translation initiation factor 4E type 1B isoform 1

      See identical proteins and their annotated locations for NP_001028441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      DQ279473, DV659735
      Consensus CDS
      CCDS49269.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000123294.1, OTTMUSP00000043463, ENSMUST00000132728.7, OTTMUST00000081297
      Conserved Domains (1) summary
      pfam01652
      Location:69225
      IF4E; Eukaryotic initiation factor 4E
    2. NM_001039683.2NP_001034772.1  eukaryotic translation initiation factor 4E type 1B isoform 2

      See identical proteins and their annotated locations for NP_001034772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DQ279474, DV659735
      Consensus CDS
      CCDS49270.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000120619.1, OTTMUSP00000043461, ENSMUST00000152204.2, OTTMUST00000081295
      Conserved Domains (1) summary
      pfam01652
      Location:69161
      IF4E; Eukaryotic initiation factor 4E
    3. NM_001286178.1NP_001273107.1  eukaryotic translation initiation factor 4E type 1B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV653822, DV659735
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000117092.1, OTTMUSP00000043466, ENSMUST00000142158.7, OTTMUST00000081300
      Conserved Domains (1) summary
      pfam01652
      Location:74230
      IF4E; Eukaryotic initiation factor 4E
    4. NM_001286179.1NP_001273108.1  eukaryotic translation initiation factor 4E type 1B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (4) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV659735, DV662251
      Consensus CDS
      CCDS70460.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      UniProtKB/TrEMBL
      E9PVZ9
      Related
      ENSMUSP00000118697.2, OTTMUSP00000043468, ENSMUST00000126785.7, OTTMUST00000081302
      Conserved Domains (1) summary
      pfam01652
      Location:75231
      IF4E; Eukaryotic initiation factor 4E
    5. NM_001286180.1NP_001273109.1  eukaryotic translation initiation factor 4E type 1B isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate splice sites in the 5'-terminal exon and in the 3' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (5) has a longer N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV659735, DV662389
      Consensus CDS
      CCDS70459.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      UniProtKB/TrEMBL
      E9Q929
      Related
      ENSMUSP00000116681.1, OTTMUSP00000043467, ENSMUST00000132005.7, OTTMUST00000081301
      Conserved Domains (1) summary
      pfam01652
      Location:74166
      IF4E; Eukaryotic initiation factor 4E

    RNA

    1. NR_104406.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      DQ279473, DQ279478, DV659735
    2. NR_104407.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two internal exons and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      DQ279473, DQ279479, DV659735

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      54783928..54788459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315486.1XP_017170975.1  eukaryotic translation initiation factor 4E type 1B isoform X2

      UniProtKB/Swiss-Prot
      Q3UTA9
      Conserved Domains (1) summary
      pfam01652
      Location:69161
      IF4E; Eukaryotic initiation factor 4E
    2. XM_017315485.1XP_017170974.1  eukaryotic translation initiation factor 4E type 1B isoform X1

      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000105630.2, OTTMUSP00000043460, ENSMUST00000110003.8, OTTMUST00000081294
      Conserved Domains (1) summary
      pfam01652
      Location:69225
      IF4E; Eukaryotic initiation factor 4E
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