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    Tsc22d1 TSC22 domain family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 21807, updated on 2-Oct-2018

    Summary

    Official Symbol
    Tsc22d1provided by MGI
    Official Full Name
    TSC22 domain family, member 1provided by MGI
    Primary source
    MGI:MGI:109127
    See related
    Ensembl:ENSMUSG00000022010 Vega:OTTMUSG00000026106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsc; Egr5; Tsc22; TSC-22; Tgfb1i4; AA589566; AW105905
    Expression
    Ubiquitous expression in adrenal adult (RPKM 53.8), CNS E14 (RPKM 43.9) and 27 other tissues See more
    Orthologs

    Genomic context

    See Tsc22d1 in Genome Data Viewer
    Location:
    14 D3; 14 40.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (76414635..76507765)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (76815628..76907573)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900040C04 gene Neighboring gene predicted gene, 41215 Neighboring gene RIKEN cDNA 4930444M15 gene Neighboring gene predicted gene, 36845 Neighboring gene stress-associated endoplasmic reticulum protein family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    TSC22 domain family protein 1
    Names
    Tgfb-stimulated clone 22 homolog
    Tsc22-related inducible leucine zipper 1b
    regulatory protein Tsc22
    transforming growth factor beta 1 induced transcript 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177751.2NP_001171222.1  TSC22 domain family protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC142266, AI841546, AK147039, BY720238
      Consensus CDS
      CCDS49545.1
      UniProtKB/TrEMBL
      D3YW86, Q3UXU0
      Related
      ENSMUSP00000099140.2, OTTMUSP00000032007, ENSMUST00000101618.8, OTTMUST00000064453
      Conserved Domains (1) summary
      pfam01166
      Location:2268
      TSC22; TSC-22/dip/bun family
    2. NM_001310646.1NP_001297575.1  TSC22 domain family protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001297575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate splice structure in its 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC134842, AI841546, AW546174, CX220910
      Consensus CDS
      CCDS79344.1
      UniProtKB/TrEMBL
      D3Z0V7
      Related
      ENSMUSP00000106513.1, OTTMUSP00000032021, ENSMUST00000110888.7, OTTMUST00000064475
      Conserved Domains (1) summary
      pfam01166
      Location:910956
      TSC22; TSC-22/dip/bun family
    3. NM_001310647.1NP_001297576.1  TSC22 domain family protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001297576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks the 5' and central coding regions, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (5) is significantly shorter than isoform 1.
      Source sequence(s)
      AI841546, AW546174, CX220910
      Consensus CDS
      CCDS79345.1
      UniProtKB/TrEMBL
      H3BLI9
      Related
      ENSMUSP00000135296.1, OTTMUSP00000061654, ENSMUST00000177207.1, OTTMUST00000064455
      Conserved Domains (1) summary
      pfam01166
      Location:147
      TSC22; TSC-22/dip/bun family
    4. NM_009366.4NP_033392.1  TSC22 domain family protein 1 isoform 2

      See identical proteins and their annotated locations for NP_033392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI841546, AK147039
      Consensus CDS
      CCDS27286.1
      UniProtKB/Swiss-Prot
      P62500
      UniProtKB/TrEMBL
      Q3UXU0
      Related
      ENSMUSP00000022587.9, OTTMUSP00000032005, ENSMUST00000022587.9, OTTMUST00000064451
      Conserved Domains (1) summary
      pfam01166
      Location:58104
      TSC22; TSC-22/dip/bun family
    5. NM_207652.3NP_997535.2  TSC22 domain family protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI841546, AK147039, BC058660
      Consensus CDS
      CCDS27285.2
      UniProtKB/Swiss-Prot
      P62500
      UniProtKB/TrEMBL
      E9QLZ1, Q3UXU0
      Related
      ENSMUSP00000044517.8, OTTMUSP00000032006, ENSMUST00000048371.14, OTTMUST00000064452
      Conserved Domains (1) summary
      pfam01166
      Location:9921038
      TSC22; TSC-22/dip/bun family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      76414635..76507765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315944.1XP_017171433.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/TrEMBL
      E9QLZ1
      Conserved Domains (1) summary
      pfam01166
      Location:9921038
      TSC22; TSC-22/dip/bun family
    2. XM_017315943.1XP_017171432.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/TrEMBL
      E9QLZ1
      Conserved Domains (1) summary
      pfam01166
      Location:9921038
      TSC22; TSC-22/dip/bun family
    3. XM_017315945.1XP_017171434.1  TSC22 domain family protein 1 isoform X5

      Conserved Domains (1) summary
      pfam03153
      Location:700879
      TFIIA; Transcription factor IIA, alpha/beta subunit
    4. XM_006518799.2XP_006518862.1  TSC22 domain family protein 1 isoform X2

      Conserved Domains (1) summary
      pfam03153
      Location:700879
      TFIIA; Transcription factor IIA, alpha/beta subunit
    5. XM_006518801.2XP_006518864.1  TSC22 domain family protein 1 isoform X4

      Conserved Domains (1) summary
      pfam03153
      Location:700879
      TFIIA; Transcription factor IIA, alpha/beta subunit
    6. XM_006518800.2XP_006518863.1  TSC22 domain family protein 1 isoform X3

      Conserved Domains (1) summary
      pfam03153
      Location:700879
      TFIIA; Transcription factor IIA, alpha/beta subunit
    7. XM_017315942.1XP_017171431.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/TrEMBL
      E9QLZ1
      Conserved Domains (1) summary
      pfam01166
      Location:9921038
      TSC22; TSC-22/dip/bun family
    8. XM_006518803.3XP_006518866.1  TSC22 domain family protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006518866.1

      UniProtKB/TrEMBL
      D3Z0V7
      Conserved Domains (1) summary
      pfam01166
      Location:910956
      TSC22; TSC-22/dip/bun family

    RNA

    1. XR_001781104.1 RNA Sequence

    2. XR_001781105.1 RNA Sequence

    3. XR_383154.2 RNA Sequence

    4. XR_383156.2 RNA Sequence

    5. XR_383155.2 RNA Sequence

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