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    Tgfa transforming growth factor alpha [ Mus musculus (house mouse) ]

    Gene ID: 21802, updated on 14-May-2024

    Summary

    Official Symbol
    Tgfaprovided by MGI
    Official Full Name
    transforming growth factor alphaprovided by MGI
    Primary source
    MGI:MGI:98724
    See related
    Ensembl:ENSMUSG00000029999 AllianceGenome:MGI:98724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    wa1; wa-1
    Summary
    This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in ovary adult (RPKM 6.7), CNS E18 (RPKM 6.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Tgfa in Genome Data Viewer
    Location:
    6 D1; 6 37.62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86172020..86252726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86195038..86275744)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adducin 2 Neighboring gene predicted gene, 19596 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 40S ribosomal protein S28 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERBB2-EGFR signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protransforming growth factor alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403118.1NP_001390047.1  protransforming growth factor alpha isoform 2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC159549
    2. NM_031199.5NP_112476.1  protransforming growth factor alpha isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_112476.1

      Status: REVIEWED

      Source sequence(s)
      AC159549
      Consensus CDS
      CCDS51832.1
      UniProtKB/Swiss-Prot
      P48030
      UniProtKB/TrEMBL
      Q545E4
      Related
      ENSMUSP00000032066.10, ENSMUST00000032066.13
      Conserved Domains (2) summary
      PHA02887
      Location:4382
      PHA02887; EGF-like protein; Provisional
      PHA03099
      Location:46120
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86172020..86252726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255312.1XP_030111172.1  protransforming growth factor alpha isoform X1

      Conserved Domains (2) summary
      PHA02887
      Location:4382
      PHA02887; EGF-like protein; Provisional
      PHA03099
      Location:46120
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional