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    Larp4b La ribonucleoprotein domain family, member 4B [ Mus musculus (house mouse) ]

    Gene ID: 217980, updated on 23-Jun-2021

    Summary

    Official Symbol
    Larp4bprovided by MGI
    Official Full Name
    La ribonucleoprotein domain family, member 4Bprovided by MGI
    Primary source
    MGI:MGI:106330
    See related
    Ensembl:ENSMUSG00000033499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; Larp5; AI256361; D13Wsu64; D13Wsu64e; A630096F19
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.9), liver E14 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Larp4b in Genome Data Viewer
    Location:
    13 A1; 13 3.66 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (9143643..9224487)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (9093653..9174451)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (9093151..9172355)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene GTP binding protein 4 Neighboring gene predicted gene, 36264 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene 8784 Neighboring gene predicted gene, 46391

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC78318

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in polysomal ribosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    la-related protein 4B
    Names
    La ribonucleoprotein domain family, member 5
    la ribonucleoprotein domain family member 5
    la-related protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311117.1NP_001298046.1  la-related protein 4B isoform 2

      See identical proteins and their annotated locations for NP_001298046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC125484, AC131743, BC059218, BU056450, CF540574, CF950134
      Consensus CDS
      CCDS79162.1
      UniProtKB/Swiss-Prot
      Q6A0A2
      Related
      ENSMUSP00000089437.4, ENSMUST00000091829.4
      Conserved Domains (2) summary
      cd08036
      Location:159233
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:238314
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_172585.3NP_766173.1  la-related protein 4B isoform 1

      See identical proteins and their annotated locations for NP_766173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125484, AC131743, BC059218, BU056450, CF540574, CF950134
      Consensus CDS
      CCDS36588.1
      UniProtKB/Swiss-Prot
      Q6A0A2
      Related
      ENSMUSP00000140993.2, ENSMUST00000188211.8
      Conserved Domains (2) summary
      cd08036
      Location:159233
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:238314
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      9143643..9224487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516476.4XP_006516539.1  la-related protein 4B isoform X3

      See identical proteins and their annotated locations for XP_006516539.1

      UniProtKB/Swiss-Prot
      Q6A0A2
      Conserved Domains (2) summary
      cd08036
      Location:159233
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:238314
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)
    2. XM_036157976.1XP_036013869.1  la-related protein 4B isoform X3

      Conserved Domains (2) summary
      cd08036
      Location:159233
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:238314
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)
    3. XM_011244254.4XP_011242556.1  la-related protein 4B isoform X2

      Conserved Domains (2) summary
      cd08036
      Location:11411215
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:12201296
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
    4. XM_011244253.4XP_011242555.1  la-related protein 4B isoform X1

      Conserved Domains (2) summary
      cd08036
      Location:11411215
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:12201296
      RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)
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