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    Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [ Mus musculus (house mouse) ]

    Gene ID: 217944, updated on 7-Aug-2018

    Summary

    Official Symbol
    Rapgef5provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
    Primary source
    MGI:MGI:2444365
    See related
    Ensembl:ENSMUSG00000041992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GFR; Mrgef; C86120; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
    Expression
    Broad expression in lung adult (RPKM 12.6), cortex adult (RPKM 11.5) and 23 other tissues See more
    Orthologs

    Genomic context

    See Rapgef5 in Genome Data Viewer
    Location:
    12; 12 F2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (117516479..117759737)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (118754952..118995451)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, N polypeptide 2 Neighboring gene predicted gene 5441 Neighboring gene microRNA 153 Neighboring gene predicted gene, 31482 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene dynein, axonemal, heavy chain 11 Neighboring gene trans-acting transcription factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rap guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 5
    Names
    M-Ras-regulated Rap GEF
    MR-GEF
    Mras regulated guanine nucleotide exchange factor
    guanine nucleotide exchange factor for Rap1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175930.5NP_787126.3  rap guanine nucleotide exchange factor 5

      See identical proteins and their annotated locations for NP_787126.3

      Status: VALIDATED

      Source sequence(s)
      AC139993, AC163286, AK029995
      Consensus CDS
      CCDS36577.1
      UniProtKB/Swiss-Prot
      Q8C0Q9
      Related
      ENSMUSP00000105313.2, ENSMUST00000109691.3
      Conserved Domains (3) summary
      smart00147
      Location:574813
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:302433
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:33156
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      117516479..117759737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515781.3XP_006515844.1  rap guanine nucleotide exchange factor 5 isoform X1

      Conserved Domains (3) summary
      smart00147
      Location:682921
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:410541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:141264
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
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