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    Tfg Trk-fused gene [ Mus musculus (house mouse) ]

    Gene ID: 21787, updated on 18-Sep-2018

    Summary

    Official Symbol
    Tfgprovided by MGI
    Official Full Name
    Trk-fused geneprovided by MGI
    Primary source
    MGI:MGI:1338041
    See related
    Ensembl:ENSMUSG00000022757 Vega:OTTMUSG00000026667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI173908
    Expression
    Ubiquitous expression in duodenum adult (RPKM 162.5), small intestine adult (RPKM 131.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tfg in Genome Data Viewer
    Location:
    16; 16 C1.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (56690329..56717532, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (56690445..56717467, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene discs, large homolog-associated protein 5 pseudogene Neighboring gene ABI gene family, member 3 (NESH) binding protein Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene predicted gene 15693 Neighboring gene transmembrane protein 45a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252443.1NP_001239372.1  protein TFG isoform 2

      See identical proteins and their annotated locations for NP_001239372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      CT025158
      UniProtKB/TrEMBL
      Q8C2C6
      Conserved Domains (1) summary
      cd06401
      Location:1189
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    2. NM_001357124.1NP_001344053.1  protein TFG isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025158
      Conserved Domains (1) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    3. NM_001357125.1NP_001344054.1  protein TFG isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025158
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:291393
      dnaA; chromosomal replication initiation protein; Provisional
    4. NM_001357126.1NP_001344055.1  protein TFG isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT025158
      Conserved Domains (1) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    5. NM_019678.3NP_062652.1  protein TFG isoform 1

      See identical proteins and their annotated locations for NP_062652.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AK158539, BB783895, BB856666, BY061830
      Consensus CDS
      CCDS28224.1
      UniProtKB/TrEMBL
      Q9Z1A1
      Related
      ENSMUSP00000067867.7, OTTMUSP00000032965, ENSMUST00000065515.13, OTTMUST00000065984
      Conserved Domains (1) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      56690329..56717532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521980.2XP_006522043.1  protein TFG isoform X1

      See identical proteins and their annotated locations for XP_006522043.1

      UniProtKB/TrEMBL
      Q9Z1A1
      Conserved Domains (1) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    2. XM_006521983.3XP_006522046.1  protein TFG isoform X4

      Conserved Domains (1) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    3. XM_006521981.3XP_006522044.1  protein TFG isoform X2

      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:291393
      dnaA; chromosomal replication initiation protein; Provisional
    4. XM_006521982.3XP_006522045.1  protein TFG isoform X3

      Conserved Domains (1) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
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