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    Eif5 eukaryotic translation initiation factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 217869, updated on 22-Aug-2021

    Summary

    Official Symbol
    Eif5provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5provided by MGI
    Primary source
    MGI:MGI:95309
    See related
    Ensembl:ENSMUSG00000021282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd549; D12Ertd549e; 2810011H21Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 62.4), CNS E11.5 (RPKM 53.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif5 in Genome Data Viewer
    Location:
    12 F1; 12 61.03 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111504535..111513187)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111538101..111546753)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (112776312..112784964)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor, alpha-induced protein 2 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene RIKEN cDNA 2810029C07 gene Neighboring gene MAP/microtubule affinity regulating kinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36374, MGC36509

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic initiation factor eIF2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables eukaryotic initiation factor eIF2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 5
    Names
    eIF-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173363.5NP_775539.1  eukaryotic translation initiation factor 5

      See identical proteins and their annotated locations for NP_775539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represent the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI391022, AK160828, AK163368, AW547465
      Consensus CDS
      CCDS26180.1
      UniProtKB/Swiss-Prot
      P59325
      UniProtKB/TrEMBL
      Q3TQR3
      Related
      ENSMUSP00000126825.2, ENSMUST00000166123.9
      Conserved Domains (2) summary
      cd11561
      Location:231383
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:9128
      eIF-5_eIF-2B; Domain found in IF2B/IF5
    2. NM_178041.2NP_829887.1  eukaryotic translation initiation factor 5

      See identical proteins and their annotated locations for NP_829887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI391022, AK159232, AK160828, AW547465
      Consensus CDS
      CCDS26180.1
      UniProtKB/Swiss-Prot
      P59325
      UniProtKB/TrEMBL
      Q3TQR3
      Related
      ENSMUSP00000152791.2, ENSMUST00000222375.2
      Conserved Domains (2) summary
      cd11561
      Location:231383
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:9128
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111504535..111513187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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