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    Cdc42bpb CDC42 binding protein kinase beta [ Mus musculus (house mouse) ]

    Gene ID: 217866, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc42bpbprovided by MGI
    Official Full Name
    CDC42 binding protein kinase betaprovided by MGI
    Primary source
    MGI:MGI:2136459
    See related
    Ensembl:ENSMUSG00000021279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRCKb
    Expression
    Ubiquitous expression in ovary adult (RPKM 53.7), adrenal adult (RPKM 48.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdc42bpb in Genome Data Viewer
    Location:
    12 F1; 12 60.94 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (111292972..111377718, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (112531183..112615929, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene amnionless Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Rho GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actomyosin ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase MRCK beta
    Names
    DMPK-like beta
    MRCK beta
    cdc42bpb
    myotonic dystrophy kinase related CDC42 binding kinase beta
    myotonic dystrophy protein kinase like beta
    NP_898837.2
    XP_006515826.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183016.2NP_898837.2  serine/threonine-protein kinase MRCK beta

      See identical proteins and their annotated locations for NP_898837.2

      Status: VALIDATED

      Source sequence(s)
      AC127580
      Consensus CDS
      CCDS26176.1
      UniProtKB/Swiss-Prot
      Q7TT50
      Related
      ENSMUSP00000042565.3, ENSMUST00000041965.4
      Conserved Domains (8) summary
      pfam08826
      Location:878939
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:10271076
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:10861220
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:12461512
      CNH; CNH domain
      pfam13868
      Location:426786
      TPH; Trichohyalin-plectin-homology domain
      pfam15796
      Location:528606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      111292972..111377718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515763.2XP_006515826.1  serine/threonine-protein kinase MRCK beta isoform X1

      Conserved Domains (8) summary
      pfam08826
      Location:878939
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:10441093
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:11031237
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:12631529
      CNH; CNH domain
      pfam13868
      Location:426786
      TPH; Trichohyalin-plectin-homology domain
      pfam15796
      Location:528606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RNA

    1. XR_001780447.1 RNA Sequence

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