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    Ahsa1 AHA1, activator of heat shock protein ATPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 217737, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ahsa1provided by MGI
    Official Full Name
    AHA1, activator of heat shock protein ATPase 1provided by MGI
    Primary source
    MGI:MGI:2387603
    See related
    Ensembl:ENSMUSG00000021037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p38; BC023857
    Expression
    Ubiquitous expression in liver E14 (RPKM 69.2), CNS E11.5 (RPKM 67.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ahsa1 in Genome Data Viewer
    Location:
    12; 12 D2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (87266484..87273998)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (88607678..88614902)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene NADP+ dependent oxidoreductase domain containing 1 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene isthmin 2 Neighboring gene serine palmitoyltransferase, long chain base subunit 2 Neighboring gene predicted gene, 33444

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36589, MGC36618

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    activator of 90 kDa heat shock protein ATPase homolog 1
    Names
    AHA1, activator of heat shock 90kDa protein ATPase homolog 1
    AHA1, activator of heat shock protein ATPase homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146036.2NP_666148.1  activator of 90 kDa heat shock protein ATPase homolog 1

      See identical proteins and their annotated locations for NP_666148.1

      Status: VALIDATED

      Source sequence(s)
      AC151967
      Consensus CDS
      CCDS26075.1
      UniProtKB/Swiss-Prot
      Q8BK64
      Related
      ENSMUSP00000021425.6, ENSMUST00000021425.7
      Conserved Domains (2) summary
      cd08892
      Location:208333
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      smart01000
      Location:29158
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      87266484..87273998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515729.1XP_006515792.1  activator of 90 kDa heat shock protein ATPase homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006515792.1

      Conserved Domains (1) summary
      cd08892
      Location:73198
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
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