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    Sipa1l1 signal-induced proliferation-associated 1 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 217692, updated on 9-Sep-2018

    Summary

    Official Symbol
    Sipa1l1provided by MGI
    Official Full Name
    signal-induced proliferation-associated 1 like 1provided by MGI
    Primary source
    MGI:MGI:2443679
    See related
    Ensembl:ENSMUSG00000042700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spar; AW213287; mKIAA0440; 4931426N11Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 37.5), cortex adult (RPKM 30.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See Sipa1l1 in Genome Data Viewer
    Location:
    12; 12 D1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (82169378..82451786)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (83271003..83552773)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene pecanex homolog Neighboring gene predicted gene, 30799 Neighboring gene predicted gene, 30916 Neighboring gene predicted gene, 31064 Neighboring gene predicted gene, 30966 Neighboring gene general transcription factor II A, 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    signal-induced proliferation-associated 1-like protein 1
    Names
    SIPA1-like protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167983.1NP_001161455.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001161455.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to variant 1, resulting in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK078420, AK122284, BC058681, BP765364
      Consensus CDS
      CCDS49105.1
      UniProtKB/Swiss-Prot
      Q8C0T5
      Related
      ENSMUSP00000152356.1, ENSMUST00000222298.1
      Conserved Domains (3) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    2. NM_172579.3NP_766167.2  signal-induced proliferation-associated 1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_766167.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK029889, AK122284, BP765364
      Consensus CDS
      CCDS26026.1
      UniProtKB/Swiss-Prot
      Q8C0T5
      Related
      ENSMUSP00000061014.6, ENSMUST00000053969.6
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      82169378..82451786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315026.1XP_017170515.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    2. XM_011244060.2XP_011242362.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242362.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    3. XM_011244067.2XP_011242369.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17281783
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961740
      SPAR_C; C-terminal domain of SPAR protein
    4. XM_011244068.2XP_011242370.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17161771
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14831728
      SPAR_C; C-terminal domain of SPAR protein
    5. XM_011244069.2XP_011242371.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011242371.1

      UniProtKB/Swiss-Prot
      Q8C0T5
      Related
      ENSMUSP00000131030.2, ENSMUST00000166429.8
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    6. XM_011244061.2XP_011242363.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242363.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    7. XM_017315025.1XP_017170514.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8C0T5
      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17151770
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14831727
      SPAR_C; C-terminal domain of SPAR protein
    8. XM_017315027.1XP_017170516.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    9. XM_017315028.1XP_017170517.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    10. XM_011244064.2XP_011242366.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242366.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    11. XM_011244066.2XP_011242368.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242368.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    12. XM_011244063.2XP_011242365.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242365.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    13. XM_011244062.2XP_011242364.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011242364.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    14. XM_006515684.3XP_006515747.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515747.1

      Conserved Domains (4) summary
      cd00992
      Location:9531023
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:629809
      Rap_GAP; Rap/ran-GAP
      pfam06005
      Location:17291784
      DUF904; Protein of unknown function (DUF904)
      pfam11881
      Location:14961741
      SPAR_C; C-terminal domain of SPAR protein
    15. XM_017315029.1XP_017170518.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

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