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    Morf4l1 mortality factor 4 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 21761, updated on 5-Sep-2021

    Summary

    Official Symbol
    Morf4l1provided by MGI
    Official Full Name
    mortality factor 4 like 1provided by MGI
    Primary source
    MGI:MGI:1096551
    See related
    Ensembl:ENSMUSG00000062270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRG1; MORFR; MRG15; Tex189; TEG-189; MORFRG15; mKIAA4002
    Expression
    Broad expression in testis adult (RPKM 222.1), CNS E11.5 (RPKM 158.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Morf4l1 in Genome Data Viewer
    Location:
    9; 9 E3.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89973722..89996873, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (90091669..90114820, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (89986507..90009658, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene thymidine kinase 1 pseudogene Neighboring gene cathepsin H Neighboring gene transmembrane protein 41B, pseudogene Neighboring gene nuclear encoded tRNA lysine 18 (anticodon CTT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA4002, MGC102415, MGC103105, MGC118047

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H2A acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Sin3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mortality factor 4-like protein 1
    Names
    MORF-related gene 15 protein
    testis expressed gene 189
    testis-expressed gene 189 protein
    transcription factor-like protein MRG15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039147.2NP_001034236.1  mortality factor 4-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001034236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC140392, BC085103
      Consensus CDS
      CCDS23400.1
      UniProtKB/Swiss-Prot
      P60762
      Related
      ENSMUSP00000082346.6, ENSMUST00000085248.12
      Conserved Domains (2) summary
      cd18983
      Location:15110
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:184351
      MRG
    2. NM_001357780.1NP_001344709.1  mortality factor 4-like protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC140392
      Conserved Domains (2) summary
      cd18983
      Location:15109
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:183350
      MRG
    3. NM_024431.3NP_077751.1  mortality factor 4-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_077751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC140392, AK167079, BC085103
      Consensus CDS
      CCDS52885.1
      UniProtKB/Swiss-Prot
      P60762
      UniProtKB/TrEMBL
      Q569V4
      Related
      ENSMUSP00000132020.2, ENSMUST00000169860.8
      Conserved Domains (2) summary
      cd18983
      Location:1571
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:145312
      MRG

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      89973722..89996873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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