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    Mbip MAP3K12 binding inhibitory protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 217588, updated on 8-Feb-2024


    Official Symbol
    Mbipprovided by MGI
    Official Full Name
    MAP3K12 binding inhibitory protein 1provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000021028 AllianceGenome:MGI:1918320
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Predicted to enable identical protein binding activity and protein kinase inhibitor activity. Predicted to be involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Located in nucleus. Part of ATAC complex. Is expressed in lung and telencephalon. Orthologous to human MBIP (MAP3K12 binding inhibitory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in CNS E14 (RPKM 9.9), CNS E11.5 (RPKM 9.1) and 26 other tissues See more
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    Genomic context

    See Mbip in Genome Data Viewer
    12 C1; 12 24.3 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56375091..56392681, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56328306..56345933, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19990 Neighboring gene predicted gene, 46351 Neighboring gene STARR-seq mESC enhancer starr_32208 Neighboring gene predicted gene, 53723 Neighboring gene STARR-positive B cell enhancer ABC_E2385 Neighboring gene cytochrome c oxidase subunit 6C2 Neighboring gene STARR-positive B cell enhancer ABC_E5330 Neighboring gene STARR-positive B cell enhancer ABC_E8887 Neighboring gene STARR-positive B cell enhancer ABC_E10750 Neighboring gene predicted gene, 18027

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Clone Names

    • MGC7681

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    located_in nucleus IDA
    Inferred from Direct Assay
    more info

    General protein information

    Preferred Names
    MAP3K12-binding inhibitory protein 1
    MAPK upstream kinase-binding inhibitory protein
    MUK-binding inhibitory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145442.2NP_663417.1  MAP3K12-binding inhibitory protein 1

      See identical proteins and their annotated locations for NP_663417.1

      Status: VALIDATED

      Source sequence(s)
      AC154714, AK077125
      Consensus CDS
      Q3TBM3, Q99LQ1
      ENSMUSP00000021416.8, ENSMUST00000021416.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000078.7 Reference GRCm39 C57BL/6J

      56375091..56392681 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246648.2XP_030102508.1  MAP3K12-binding inhibitory protein 1 isoform X3

    2. XM_006515674.5XP_006515737.1  MAP3K12-binding inhibitory protein 1 isoform X2

    3. XM_006515673.5XP_006515736.1  MAP3K12-binding inhibitory protein 1 isoform X1

    4. XM_017315023.3XP_017170512.1  MAP3K12-binding inhibitory protein 1 isoform X5

    5. XM_017315021.3XP_017170510.1  MAP3K12-binding inhibitory protein 1 isoform X4


    1. XR_004937488.1 RNA Sequence

    2. XR_004937487.1 RNA Sequence