Format

Send to:

Choose Destination
    • Showing Current items.

    Nploc4 NPL4 homolog, ubiquitin recognition factor [ Mus musculus (house mouse) ]

    Gene ID: 217365, updated on 5-Aug-2018

    Summary

    Official Symbol
    Nploc4provided by MGI
    Official Full Name
    NPL4 homolog, ubiquitin recognition factorprovided by MGI
    Primary source
    MGI:MGI:2679787
    See related
    Ensembl:ENSMUSG00000039703 Vega:OTTMUSG00000004173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npl4; AK129375; mKIAA1499
    Expression
    Ubiquitous expression in testis adult (RPKM 28.6), ovary adult (RPKM 21.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nploc4 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (120379798..120437700, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120241685..120298982, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene fascin actin-bundling protein 2 Neighboring gene Fanconi anemia core complex associated protein 100 Neighboring gene tetraspanin 10 Neighboring gene phosphodiesterase 6G, cGMP-specific, rod, gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1499

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    UFD1-NPL4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear protein localization protein 4 homolog
    Names
    nuclear protein localization 4 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195023.1NP_001181952.1  nuclear protein localization protein 4 homolog isoform A

      See identical proteins and their annotated locations for NP_001181952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AK149912, AL669855
      Consensus CDS
      CCDS56827.1
      UniProtKB/Swiss-Prot
      P60670
      UniProtKB/TrEMBL
      Q3UDU9
      Related
      ENSMUSP00000035851.8, OTTMUSP00000004607, ENSMUST00000044271.14, OTTMUST00000009470
      Conserved Domains (4) summary
      sd00029
      Location:584603
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:105245
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:249556
      NPL4; NPL4 family
      pfam11543
      Location:679
      UN_NPL4; Nuclear pore localization protein NPL4
    2. NM_199469.2NP_955763.1  nuclear protein localization protein 4 homolog isoform B

      See identical proteins and their annotated locations for NP_955763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant A. This results in a shorter protein (isoform B), compared to isoform A.
      Source sequence(s)
      AL669855, BC065156
      Consensus CDS
      CCDS25732.1
      UniProtKB/Swiss-Prot
      P60670
      Related
      ENSMUSP00000099306.3, OTTMUSP00000004608, ENSMUST00000103017.3, OTTMUST00000009471
      Conserved Domains (5) summary
      COG5100
      Location:5528
      NPL4; Nuclear pore protein [Nuclear structure]
      sd00029
      Location:552571
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:105245
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam11543
      Location:180
      UN_NPL4; Nuclear pore localization protein NPL4
      cl13996
      Location:249524
      MPN; Mpr1p, Pad1p N-terminal (MPN) domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      120379798..120437700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533134.2XP_006533197.1  nuclear protein localization protein 4 homolog isoform X1

      Conserved Domains (3) summary
      sd00029
      Location:496515
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05020
      Location:17157
      zf-NPL4; NPL4 family, putative zinc binding region
      pfam05021
      Location:161468
      NPL4; NPL4 family
    Support Center