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    Unk unkempt family zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 217331, updated on 8-Aug-2021

    Summary

    Official Symbol
    Unkprovided by MGI
    Official Full Name
    unkempt family zinc fingerprovided by MGI
    Primary source
    MGI:MGI:2442456
    See related
    Ensembl:ENSMUSG00000020770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unkh; Zc3h5; Zc3hdc5; mKIAA1753; B230379M23Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 15.6), limb E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Unk in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115921117..115952040)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116028616..116061214)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115891636..115922508)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin beta 4 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene galactokinase 1 Neighboring gene H3.3 histone B Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D Neighboring gene WW domain binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA CDS binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA CDS binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polysome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of polysome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RING finger protein unkempt homolog
    Names
    unkempt homolog
    zinc finger CCCH domain-containing protein 5
    zinc finger CCCH type containing 5
    zinc finger CCCH type domain containing 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286006.1NP_001272935.1  RING finger protein unkempt homolog isoform 2

      See identical proteins and their annotated locations for NP_001272935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK134361, BB619163, BC033048
      Consensus CDS
      CCDS70351.1
      UniProtKB/TrEMBL
      Q3UYU7
      Related
      ENSMUSP00000102060.2, ENSMUST00000106452.2
      Conserved Domains (3) summary
      pfam00642
      Location:294318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam05384
      Location:633706
      DegS; Sensor protein DegS
      pfam13920
      Location:752788
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    2. NM_172569.4NP_766157.1  RING finger protein unkempt homolog isoform 1

      See identical proteins and their annotated locations for NP_766157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK046395, BB619163, BC033048
      Consensus CDS
      CCDS25655.1
      UniProtKB/Swiss-Prot
      Q8BL48
      Related
      ENSMUSP00000021116.6, ENSMUST00000021116.12
      Conserved Domains (3) summary
      pfam00642
      Location:294318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam05384
      Location:646719
      DegS; Sensor protein DegS
      pfam13920
      Location:765801
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115921117..115952040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533088.5XP_006533151.1  RING finger protein unkempt homolog isoform X1

      Conserved Domains (6) summary
      PHA03307
      Location:300571
      PHA03307; transcriptional regulator ICP4; Provisional
      COG4372
      Location:625730
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02680
      Location:485733
      TIGR02680; TIGR02680 family protein
      cd16614
      Location:740773
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:294318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18384
      Location:3469
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
    2. XM_030245897.2XP_030101757.1  RING finger protein unkempt homolog isoform X3

      Conserved Domains (5) summary
      smart00356
      Location:4771
      ZnF_C3H1; zinc finger
      COG4372
      Location:457562
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02680
      Location:317565
      TIGR02680; TIGR02680 family protein
      cd16614
      Location:572605
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:126150
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    3. XM_006533089.4XP_006533152.1  RING finger protein unkempt homolog isoform X2

      Related
      ENSMUST00000150759.8
      Conserved Domains (4) summary
      smart00356
      Location:4771
      ZnF_C3H1; zinc finger
      PRK11448
      Location:452583
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:600633
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:126150
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    4. XM_036156606.1XP_036012499.1  RING finger protein unkempt homolog isoform X5

      Conserved Domains (2) summary
      PRK11448
      Location:306437
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:454487
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    5. XM_036156605.1XP_036012498.1  RING finger protein unkempt homolog isoform X4

      Conserved Domains (2) summary
      PRK11448
      Location:319450
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:467500
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
    6. XM_017314490.3XP_017169979.1  RING finger protein unkempt homolog isoform X2

      Conserved Domains (4) summary
      smart00356
      Location:4771
      ZnF_C3H1; zinc finger
      PRK11448
      Location:452583
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:600633
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:126150
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RNA

    1. XR_001779962.3 RNA Sequence

    2. XR_001779963.3 RNA Sequence

    3. XR_001779964.3 RNA Sequence

    4. XR_003949402.2 RNA Sequence

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