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    Llgl2 LLGL2 scribble cell polarity complex component [ Mus musculus (house mouse) ]

    Gene ID: 217325, updated on 12-Aug-2018

    Summary

    Official Symbol
    Llgl2provided by MGI
    Official Full Name
    LLGL2 scribble cell polarity complex componentprovided by MGI
    Primary source
    MGI:MGI:1918843
    See related
    Ensembl:ENSMUSG00000020782 Vega:OTTMUSG00000003613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Llglh2; 9130006H11Rik
    Expression
    Broad expression in colon adult (RPKM 75.1), duodenum adult (RPKM 44.0) and 16 other tissues See more
    Orthologs

    Genomic context

    See Llgl2 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (115824029..115855780)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115685372..115717094)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene CASK-interacting protein 2 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene myosin XVB Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 

    Pathways from BioSystems

    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC27928

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    branching involved in labyrinthine layer morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment of spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment or maintenance of polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    lethal(2) giant larvae protein homolog 2
    Names
    lethal giant larvae-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252532.1NP_001239461.1  lethal(2) giant larvae protein homolog 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the central coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) has an additional segment, compared to isoform 1.
      Source sequence(s)
      AK078901, AK143486, AY033650, BY200843
      Consensus CDS
      CCDS56820.1
      UniProtKB/Swiss-Prot
      Q3TJ91
      UniProtKB/TrEMBL
      J3QJU5, Q8BVC8
      Related
      ENSMUSP00000136054.1, ENSMUST00000177736.7
      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_145438.2NP_663413.2  lethal(2) giant larvae protein homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_663413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes a shorter isoform (1).
      Source sequence(s)
      AK078901, AK167536, BE982097, BY200843
      Consensus CDS
      CCDS25649.1
      UniProtKB/Swiss-Prot
      Q3TJ91
      UniProtKB/TrEMBL
      Q8BVC8
      Related
      ENSMUSP00000099321.4, OTTMUSP00000003783, ENSMUST00000103032.10, OTTMUST00000007781
      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      115824029..115855780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533083.2XP_006533146.1  lethal(2) giant larvae protein homolog 2 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006533084.2XP_006533147.1  lethal(2) giant larvae protein homolog 2 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006533085.2XP_006533148.1  lethal(2) giant larvae protein homolog 2 isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_006533087.2XP_006533150.1  lethal(2) giant larvae protein homolog 2 isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_006533086.2XP_006533149.1  lethal(2) giant larvae protein homolog 2 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      pfam08366
      Location:272371
      LLGL; LLGL2
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:29253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_388419.2 RNA Sequence

    2. XR_388418.2 RNA Sequence

    3. XR_388421.2 RNA Sequence

    4. XR_388422.3 RNA Sequence

    5. XR_388420.2 RNA Sequence

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