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    Llgl2 LLGL2 scribble cell polarity complex component [ Mus musculus (house mouse) ]

    Gene ID: 217325, updated on 23-Jun-2021

    Summary

    Official Symbol
    Llgl2provided by MGI
    Official Full Name
    LLGL2 scribble cell polarity complex componentprovided by MGI
    Primary source
    MGI:MGI:1918843
    See related
    Ensembl:ENSMUSG00000020782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Llglh2; 9130006H11Rik
    Expression
    Broad expression in colon adult (RPKM 75.1), duodenum adult (RPKM 44.0) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Llgl2 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115714855..115746606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115824029..115855780)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115685372..115717094)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene CASK-interacting protein 2 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene myosin XVB Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC27928

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leucine transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    LLGL scribble cell polarity complex component 2
    Names
    lethal giant larvae-like protein 2
    lethal(2) giant larvae protein homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252532.1NP_001239461.1  LLGL scribble cell polarity complex component 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the central coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) has an additional segment, compared to isoform 1.
      Source sequence(s)
      AK078901, AK143486, AY033650, BY200843
      Consensus CDS
      CCDS56820.1
      UniProtKB/Swiss-Prot
      Q3TJ91
      UniProtKB/TrEMBL
      J3QJU5, Q8BVC8
      Related
      ENSMUSP00000136054.2, ENSMUST00000177736.8
      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    2. NM_145438.2NP_663413.2  LLGL scribble cell polarity complex component 2 isoform 1

      See identical proteins and their annotated locations for NP_663413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes a shorter isoform (1).
      Source sequence(s)
      AK078901, AK167536, BE982097, BY200843
      Consensus CDS
      CCDS25649.1
      UniProtKB/Swiss-Prot
      Q3TJ91
      UniProtKB/TrEMBL
      Q8BVC8
      Related
      ENSMUSP00000099321.5, ENSMUST00000103032.11
      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115714855..115746606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245894.1XP_030101754.1  LLGL scribble cell polarity complex component 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    2. XM_006533083.2XP_006533146.1  LLGL scribble cell polarity complex component 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    3. XM_006533084.2XP_006533147.1  LLGL scribble cell polarity complex component 2 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    4. XM_006533085.2XP_006533148.1  LLGL scribble cell polarity complex component 2 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    5. XM_006533087.2XP_006533150.1  LLGL scribble cell polarity complex component 2 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    6. XM_006533086.4XP_006533149.1  LLGL scribble cell polarity complex component 2 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2
    7. XM_030245895.1XP_030101755.1  LLGL scribble cell polarity complex component 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:36267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:3567
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271371
      LLGL; LLGL2

    RNA

    1. XR_388421.2 RNA Sequence

    2. XR_388422.3 RNA Sequence

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