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    Cdc27 cell division cycle 27 [ Mus musculus (house mouse) ]

    Gene ID: 217232, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cdc27provided by MGI
    Official Full Name
    cell division cycle 27provided by MGI
    Primary source
    MGI:MGI:102685
    See related
    Ensembl:ENSMUSG00000020687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP; APC3; AI452358; BC023187
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.7), placenta adult (RPKM 12.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdc27 in Genome Data Viewer
    Location:
    11 E1; 11 67.79 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104393350..104441446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104502524..104550620, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (104363838..104411934, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene predicted gene, 22743 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene myosin, light polypeptide 4 Neighboring gene predicted gene 11665 Neighboring gene TROVE domain family, member 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cell division cycle protein 27 homolog
    Names
    cell division cycle 27 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285988.1NP_001272917.1  cell division cycle protein 27 homolog isoform 1

      See identical proteins and their annotated locations for NP_001272917.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL603709, BC172100, BY013739
      UniProtKB/Swiss-Prot
      A2A6Q5
      Conserved Domains (5) summary
      COG0457
      Location:507768
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:573601
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:641673
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:1792
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:745775
      TPR_8; Tetratricopeptide repeat
    2. NM_001285989.1NP_001272918.1  cell division cycle protein 27 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK161143, AK161471, AL603709, BY036319
      UniProtKB/TrEMBL
      Q3TTW1
      Conserved Domains (5) summary
      COG0457
      Location:501762
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:567595
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:635667
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:1792
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:739769
      TPR_8; Tetratricopeptide repeat
    3. NM_001285990.1NP_001272919.1  cell division cycle protein 27 homolog isoform 4

      See identical proteins and their annotated locations for NP_001272919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AL603709, BC172149, BY013739
      Conserved Domains (5) summary
      COG0457
      Location:373634
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:439467
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:507539
      TPR_1; Tetratricopeptide repeat
      pfam13181
      Location:611641
      TPR_8; Tetratricopeptide repeat
      pfam13424
      Location:329400
      TPR_12; Tetratricopeptide repeat
    4. NM_145436.2NP_663411.2  cell division cycle protein 27 homolog isoform 2

      See identical proteins and their annotated locations for NP_663411.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK039377, AK148278, AK161143, AL603709, BY036319
      Consensus CDS
      CCDS36354.1
      UniProtKB/Swiss-Prot
      A2A6Q5
      UniProtKB/TrEMBL
      Q3TTW1, Q8BYJ1
      Related
      ENSMUSP00000091452.3, ENSMUST00000093923.9
      Conserved Domains (5) summary
      COG0457
      Location:502763
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:568596
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:636668
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:1792
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13181
      Location:740770
      TPR_8; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      104393350..104441446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156600.1XP_036012493.1  cell division cycle protein 27 homolog isoform X4

      Conserved Domains (2) summary
      COG0457
      Location:405666
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:471499
      TPR; TPR repeat [structural motif]
    2. XM_036156599.1XP_036012492.1  cell division cycle protein 27 homolog isoform X3

      Conserved Domains (2) summary
      COG0457
      Location:441702
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:507535
      TPR; TPR repeat [structural motif]
    3. XM_036156597.1XP_036012490.1  cell division cycle protein 27 homolog isoform X2

      Conserved Domains (2) summary
      COG0457
      Location:179440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245273
      TPR; TPR repeat [structural motif]
    4. XM_036156596.1XP_036012489.1  cell division cycle protein 27 homolog isoform X2

      Conserved Domains (2) summary
      COG0457
      Location:179440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245273
      TPR; TPR repeat [structural motif]
    5. XM_006533052.5XP_006533115.1  cell division cycle protein 27 homolog isoform X2

      See identical proteins and their annotated locations for XP_006533115.1

      Conserved Domains (2) summary
      COG0457
      Location:179440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245273
      TPR; TPR repeat [structural motif]
    6. XM_036156598.1XP_036012491.1  cell division cycle protein 27 homolog isoform X2

      Conserved Domains (2) summary
      COG0457
      Location:179440
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245273
      TPR; TPR repeat [structural motif]
    7. XM_006533050.4XP_006533113.1  cell division cycle protein 27 homolog isoform X1

      UniProtKB/Swiss-Prot
      A2A6Q5
      Related
      ENSMUSP00000102575.3, ENSMUST00000106962.9
      Conserved Domains (3) summary
      COG0457
      Location:508769
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:574602
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1792
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    8. XM_036156601.1XP_036012494.1  cell division cycle protein 27 homolog isoform X5

      Conserved Domains (2) summary
      COG0457
      Location:441701
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:507535
      TPR; TPR repeat [structural motif]
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