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    Dhx8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 [ Mus musculus (house mouse) ]

    Gene ID: 217207, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dhx8provided by MGI
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 8provided by MGI
    Primary source
    MGI:MGI:1306823
    See related
    Ensembl:ENSMUSG00000034931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx8; mDEAH6; mKIAA4096
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.1), thymus adult (RPKM 9.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dhx8 in Genome Data Viewer
    Location:
    11; 11 D
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101732956..101767358)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101594270..101628672)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 4D Neighboring gene predicted gene, 39391 Neighboring gene ets variant 4 Neighboring gene predicted gene, 39392

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    General gene information

    Homology

    Clone Names

    • KIAA4096, MGC31290

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX8
    Names
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 8
    DEAH box protein 8
    RNA helicase
    NP_659080.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144831.2NP_659080.2  ATP-dependent RNA helicase DHX8

      See identical proteins and their annotated locations for NP_659080.2

      Status: VALIDATED

      Source sequence(s)
      BB654249, BC065064
      Consensus CDS
      CCDS25479.1
      UniProtKB/Swiss-Prot
      A2A4P0
      Related
      ENSMUSP00000037251.7, ENSMUST00000039152.13
      Conserved Domains (6) summary
      smart00487
      Location:585770
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:9881070
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:606744
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:769926
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd05684
      Location:289367
      S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...
      pfam07717
      Location:11041203
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      101732956..101767358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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