Format

Send to:

Choose Destination
    • Showing Current items.

    Taok1 TAO kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 216965, updated on 5-Sep-2021

    Summary

    Official Symbol
    Taok1provided by MGI
    Official Full Name
    TAO kinase 1provided by MGI
    Primary source
    MGI:MGI:1914490
    See related
    Ensembl:ENSMUSG00000017291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psk2; Markk; Map3k16; AU020252; 2810468K05Rik; D130018F14Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.8), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Taok1 in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77419988..77516185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77529162..77625359, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77342664..77421317, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene abhydrolase domain containing 15 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23132

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29021, mKIAA1361

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO1
    Names
    serine/threonine protein kinase TAO1 homolog
    thousand and one amino acid protein 1
    NP_001351062.1
    NP_001351063.1
    NP_659074.2
    XP_006533022.1
    XP_006533023.1
    XP_011247232.1
    XP_030101697.1
    XP_036012472.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364133.1NP_001351062.1  serine/threonine-protein kinase TAO1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS36235.1
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    2. NM_001364134.1NP_001351063.1  serine/threonine-protein kinase TAO1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS36235.1
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    3. NM_144825.3NP_659074.2  serine/threonine-protein kinase TAO1

      See identical proteins and their annotated locations for NP_659074.2

      Status: VALIDATED

      Source sequence(s)
      AK013386, AK143530, AK173156, BC034906, BE691513, CF164486, CN717576, CN717636, CN718413, CN721819, CN724017, CN724388
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8
      UniProtKB/TrEMBL
      B2RX66
      Related
      ENSMUSP00000055470.8, ENSMUST00000058496.8
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77419988..77516185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245837.2XP_030101697.1  serine/threonine-protein kinase TAO1 isoform X1

      Related
      ENSMUSP00000017435.5, ENSMUST00000017435.11
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    2. XM_011248930.4XP_011247232.1  serine/threonine-protein kinase TAO1 isoform X1

      See identical proteins and their annotated locations for XP_011247232.1

      UniProtKB/Swiss-Prot
      Q5F2E8
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    3. XM_006532960.4XP_006533023.1  serine/threonine-protein kinase TAO1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:194625
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:1170
      PKc_like; Protein Kinases, catalytic domain
      cl27706
      Location:656713
      Prion; Prion/Doppel alpha-helical domain
    4. XM_006532959.5XP_006533022.1  serine/threonine-protein kinase TAO1 isoform X1

      See identical proteins and their annotated locations for XP_006533022.1

      UniProtKB/Swiss-Prot
      Q5F2E8
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    5. XM_036156579.1XP_036012472.1  serine/threonine-protein kinase TAO1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:194625
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:1170
      PKc_like; Protein Kinases, catalytic domain
      cl27706
      Location:656713
      Prion; Prion/Doppel alpha-helical domain

    RNA

    1. XR_004936918.1 RNA Sequence

    Support Center