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    Git1 GIT ArfGAP 1 [ Mus musculus (house mouse) ]

    Gene ID: 216963, updated on 24-Aug-2021

    Summary

    Official Symbol
    Git1provided by MGI
    Official Full Name
    GIT ArfGAP 1provided by MGI
    Primary source
    MGI:MGI:1927140
    See related
    Ensembl:ENSMUSG00000011877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cat-; p95C; Cat-1; p95Cat
    Expression
    Broad expression in testis adult (RPKM 225.3), cortex adult (RPKM 49.2) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Git1 in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77384114..77398600)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77493288..77507774)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77306914..77321276)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coronin 6 Neighboring gene microRNA mir-12181 Neighboring gene ankyrin repeat domain 13b Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene abhydrolase domain containing 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of postsynaptic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within immunological synapse formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in intramembranous ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in motor learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ARF protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in calyx of Held IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ARF GTPase-activating protein GIT1
    Names
    ARF GAP GIT1
    G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    G protein-coupled receptor kinase-interactor 1
    GRK-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004144.1NP_001004144.1  ARF GTPase-activating protein GIT1 isoform 1

      See identical proteins and their annotated locations for NP_001004144.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079870
      Consensus CDS
      CCDS25080.1
      UniProtKB/Swiss-Prot
      Q68FF6
      Related
      ENSMUSP00000037210.4, ENSMUST00000037285.10
      Conserved Domains (6) summary
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
      cd08846
      Location:1111
      ArfGap_GIT1; GIT1 GTPase activating protein for Arf
      pfam08518
      Location:337365
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:649763
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:418482
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    2. NM_001374758.1NP_001361687.1  ARF GTPase-activating protein GIT1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Consensus CDS
      CCDS88196.1
      Related
      ENSMUSP00000098375.4, ENSMUST00000100812.4
      Conserved Domains (6) summary
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
      cd08846
      Location:1111
      ArfGap_GIT1; GIT1 GTPase activating protein for Arf
      pfam08518
      Location:328356
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:640754
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:409473
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77384114..77398600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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