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    Dhx33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 [ Mus musculus (house mouse) ]

    Gene ID: 216877, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dhx33provided by MGI
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 33provided by MGI
    Primary source
    MGI:MGI:2445102
    See related
    Ensembl:ENSMUSG00000040620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx33; 3110057P17Rik; 9430096J02Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 8.9), ovary adult (RPKM 7.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dhx33 in Genome Data Viewer
    Location:
    11; 11 B4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (70984091..71004553, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70797593..70817934, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene nucleoporin 88 Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene Der1-like domain family, member 2 Neighboring gene RIKEN cDNA 6330403K07 gene Neighboring gene MIS12 kinetochore complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    rDNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rDNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    NLRP3 inflammasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DHX33; putative ATP-dependent RNA helicase DHX33
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33
    DEAH box protein 33
    NP_848144.3
    XP_006532990.1
    XP_011247228.1
    XP_011247229.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178367.4NP_848144.3  ATP-dependent RNA helicase DHX33

      See identical proteins and their annotated locations for NP_848144.3

      Status: VALIDATED

      Source sequence(s)
      AK087592, AL596136, BC052172
      Consensus CDS
      CCDS24971.1
      UniProtKB/Swiss-Prot
      Q80VY9
      Related
      ENSMUSP00000104167.1, ENSMUST00000108527.7
      Conserved Domains (6) summary
      smart00487
      Location:49252
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:469554
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:83225
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:282399
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:588688
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      pfam11422
      Location:409500
      IBP39; Initiator binding protein 39 kDa

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      70984091..71004553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248927.2XP_011247229.1  putative ATP-dependent RNA helicase DHX33 isoform X2

      See identical proteins and their annotated locations for XP_011247229.1

      Conserved Domains (5) summary
      smart00847
      Location:274359
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:17492
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam00271
      Location:87204
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:393493
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      pfam11422
      Location:214305
      IBP39; Initiator binding protein 39 kDa
    2. XM_011248926.1XP_011247228.1  putative ATP-dependent RNA helicase DHX33 isoform X1

      See identical proteins and their annotated locations for XP_011247228.1

      Conserved Domains (4) summary
      smart00487
      Location:49252
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:83225
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:282399
      Helicase_C; Helicase conserved C-terminal domain
      pfam04408
      Location:462500
      HA2; Helicase associated domain (HA2)
    3. XM_006532927.2XP_006532990.1  putative ATP-dependent RNA helicase DHX33 isoform X3

      See identical proteins and their annotated locations for XP_006532990.1

      Conserved Domains (3) summary
      smart00487
      Location:49252
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:83225
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:282399
      Helicase_C; Helicase conserved C-terminal domain

    RNA

    1. XR_001779954.1 RNA Sequence

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1092501..1112867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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