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    Arrb2 arrestin, beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 216869, updated on 8-Aug-2021

    Summary

    Official Symbol
    Arrb2provided by MGI
    Official Full Name
    arrestin, beta 2provided by MGI
    Primary source
    MGI:MGI:99474
    See related
    Ensembl:ENSMUSG00000060216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Arr3; AI326910; AW122872
    Expression
    Ubiquitous expression in spleen adult (RPKM 25.2), thymus adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arrb2 in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70323051..70331654)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70432485..70440828)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70246155..70254176)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12313 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene Neighboring gene microRNA 7115 Neighboring gene mediator complex subunit 11 Neighboring gene chemokine (C-X-C motif) ligand 16 Neighboring gene zinc finger, MYND-type containing 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-1A adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-1B adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables angiotensin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables follicle-stimulating hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet activating factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 1 angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 2A serotonin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in follicle-stimulating hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    beta-arrestin-2
    Names
    arrestin 3
    beta arr2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271358.1NP_001258287.1  beta-arrestin-2 isoform a

      See identical proteins and their annotated locations for NP_001258287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AL596096
      Consensus CDS
      CCDS70226.1
      UniProtKB/Swiss-Prot
      Q91YI4
      UniProtKB/TrEMBL
      J3JS97
      Related
      ENSMUSP00000104208.4, ENSMUST00000108568.10
      Conserved Domains (2) summary
      smart01017
      Location:199350
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. NM_001271359.1NP_001258288.1  beta-arrestin-2 isoform a

      See identical proteins and their annotated locations for NP_001258288.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK089542, BY201367
      Consensus CDS
      CCDS70226.1
      UniProtKB/Swiss-Prot
      Q91YI4
      UniProtKB/TrEMBL
      J3JS97
      Related
      ENSMUSP00000078065.3, ENSMUST00000079056.9
      Conserved Domains (2) summary
      smart01017
      Location:199350
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    3. NM_001271360.1NP_001258289.1  beta-arrestin-2 isoform b

      See identical proteins and their annotated locations for NP_001258289.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AL596096
      Consensus CDS
      CCDS24946.1
      UniProtKB/Swiss-Prot
      Q91YI4
      UniProtKB/TrEMBL
      A0A158SIT9
      Related
      ENSMUSP00000099623.2, ENSMUST00000102563.2
      Conserved Domains (2) summary
      smart01017
      Location:199350
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    4. NM_145429.5NP_663404.1  beta-arrestin-2 isoform b

      See identical proteins and their annotated locations for NP_663404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK159317, AL596096, BY201367
      Consensus CDS
      CCDS24946.1
      UniProtKB/Swiss-Prot
      Q91YI4
      UniProtKB/TrEMBL
      A0A158SIT9
      Related
      ENSMUSP00000099624.5, ENSMUST00000102564.11
      Conserved Domains (2) summary
      smart01017
      Location:199350
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19175
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70323051..70331654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156574.1XP_036012467.1  beta-arrestin-2 isoform X2

      Conserved Domains (2) summary
      smart01017
      Location:109260
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:685
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. XM_036156573.1XP_036012466.1  beta-arrestin-2 isoform X1

      Conserved Domains (2) summary
      smart01017
      Location:109260
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:685
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. XR_003949384.2 RNA Sequence

    2. XR_003949383.2 RNA Sequence

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