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    Usp22 ubiquitin specific peptidase 22 [ Mus musculus (house mouse) ]

    Gene ID: 216825, updated on 1-Oct-2021

    Summary

    Official Symbol
    Usp22provided by MGI
    Official Full Name
    ubiquitin specific peptidase 22provided by MGI
    Primary source
    MGI:MGI:2144157
    See related
    Ensembl:ENSMUSG00000042506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI427806
    Expression
    Broad expression in CNS E18 (RPKM 112.1), whole brain E14.5 (RPKM 101.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Usp22 in Genome Data Viewer
    Location:
    11; 11 B2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61042607..61065885, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61151781..61175059, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60965283..60988561, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene predicted gene, 42080 Neighboring gene ribosomal protein S13, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1063, MGC91200

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to H4 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiol-dependent deubiquitinase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 22
    Names
    deubiquitinating enzyme 22
    ubiquitin specific protease 22
    ubiquitin thioesterase 22
    ubiquitin thiolesterase 22
    ubiquitin-specific-processing protease 22
    NP_001004143.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004143.4NP_001004143.2  ubiquitin carboxyl-terminal hydrolase 22

      See identical proteins and their annotated locations for NP_001004143.2

      Status: VALIDATED

      Source sequence(s)
      AK160992, AL646093
      Consensus CDS
      CCDS24807.1
      UniProtKB/Swiss-Prot
      Q5DU02
      Related
      ENSMUSP00000041263.9, ENSMUST00000041683.9
      Conserved Domains (2) summary
      cd02660
      Location:176518
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:63123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61042607..61065885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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