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    Fnip1 folliculin interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 216742, updated on 31-Jan-2019

    Summary

    Official Symbol
    Fnip1provided by MGI
    Official Full Name
    folliculin interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2444668
    See related
    Ensembl:ENSMUSG00000035992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI838773; AW557298; A730024A03Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.7), placenta adult (RPKM 4.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fnip1 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (54438145..54518241)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54251681..54331743)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mucolipin 2 pseudogene Neighboring gene meiotic kinetochore factor Neighboring gene oxidative stress responsive 1 pseudogene Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6 Neighboring gene CDC42 small effector 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1961, MGC100017

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immature B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    folliculin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173753.4NP_776114.2  folliculin-interacting protein 1

      See identical proteins and their annotated locations for NP_776114.2

      Status: VALIDATED

      Source sequence(s)
      AL596127, BC079892, BY239060
      Consensus CDS
      CCDS24698.1
      UniProtKB/Swiss-Prot
      Q68FD7
      Related
      ENSMUSP00000049026.7, ENSMUST00000046835.13
      Conserved Domains (3) summary
      pfam14636
      Location:41155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:316548
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9751161
      FNIP_C; Folliculin-interacting protein C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      54438145..54518241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532849.3XP_006532912.1  folliculin-interacting protein 1 isoform X3

      Conserved Domains (3) summary
      pfam14636
      Location:41155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:288520
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9471133
      FNIP_C; Folliculin-interacting protein C-terminus
    2. XM_006532847.3XP_006532910.1  folliculin-interacting protein 1 isoform X1

      Conserved Domains (3) summary
      pfam14636
      Location:41154
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:315547
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9741160
      FNIP_C; Folliculin-interacting protein C-terminus
    3. XM_006532848.2XP_006532911.1  folliculin-interacting protein 1 isoform X2

      Conserved Domains (3) summary
      pfam14636
      Location:17131
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:292524
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9511137
      FNIP_C; Folliculin-interacting protein C-terminus
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