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    Fnip1 folliculin interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 216742, updated on 2-Nov-2024

    Summary

    Official Symbol
    Fnip1provided by MGI
    Official Full Name
    folliculin interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2444668
    See related
    Ensembl:ENSMUSG00000035992 AllianceGenome:MGI:2444668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730024A03Rik
    Summary
    Predicted to enable several functions, including ATPase inhibitor activity; enzyme activator activity; and protein-folding chaperone binding activity. Acts upstream of or within with a positive effect on negative regulation of cell population proliferation. Acts upstream of or within several processes, including immature B cell differentiation; negative regulation of TOR signaling; and regulation of apoptotic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.7), placenta adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fnip1 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54328071..54409067)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54438107..54518241)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mucolipin 2 pseudogene Neighboring gene meiotic kinetochore factor Neighboring gene oxidative stress responsive 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6983 Neighboring gene predicted gene, 57579 Neighboring gene predicted gene, 24198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54336045-54336232 Neighboring gene STARR-positive B cell enhancer ABC_E6984 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6 Neighboring gene STARR-seq mESC enhancer starr_29509 Neighboring gene STARR-seq mESC enhancer starr_29510 Neighboring gene CDC42 small effector 2 Neighboring gene predicted gene 12227

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (4)  1 citation
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1961, MGC100017

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immature B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of B cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    folliculin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173753.4NP_776114.2  folliculin-interacting protein 1

      See identical proteins and their annotated locations for NP_776114.2

      Status: VALIDATED

      Source sequence(s)
      AL596127, BC079892, BY239060
      Consensus CDS
      CCDS24698.1
      UniProtKB/Swiss-Prot
      Q68FD7, Q80T72, Q8BQM0
      Related
      ENSMUSP00000049026.8, ENSMUST00000046835.14
      Conserved Domains (3) summary
      pfam14636
      Location:41155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:316548
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9751161
      FNIP_C; Folliculin-interacting protein C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54328071..54409067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532849.5XP_006532912.1  folliculin-interacting protein 1 isoform X3

      Conserved Domains (3) summary
      pfam14636
      Location:41155
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:288520
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9471133
      FNIP_C; Folliculin-interacting protein C-terminus
    2. XM_006532847.5XP_006532910.1  folliculin-interacting protein 1 isoform X1

      Conserved Domains (3) summary
      pfam14636
      Location:41154
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:315547
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9741160
      FNIP_C; Folliculin-interacting protein C-terminus
    3. XM_006532848.4XP_006532911.1  folliculin-interacting protein 1 isoform X2

      Conserved Domains (3) summary
      pfam14636
      Location:17131
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:292524
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9511137
      FNIP_C; Folliculin-interacting protein C-terminus