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    Rufy1 RUN and FYVE domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 216724, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rufy1provided by MGI
    Official Full Name
    RUN and FYVE domain containing 1provided by MGI
    Primary source
    MGI:MGI:2429762
    See related
    Ensembl:ENSMUSG00000020375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ra; Rabip4; ZFYVE1; ZFYVE12; 3000002E04Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 5.9), adrenal adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rufy1 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50280113..50322101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50389286..50431274, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (50202805..50244613, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53701 Neighboring gene microRNA 804 Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene predicted gene, 53702 Neighboring gene predicted gene, 36763

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RUN and FYVE domain-containing protein 1
    Names
    FYVE-finger containing protein
    Rab4a interacting protein
    rab4-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172557.3NP_766145.1  RUN and FYVE domain-containing protein 1

      See identical proteins and their annotated locations for NP_766145.1

      Status: VALIDATED

      Source sequence(s)
      AK046625, AK046633, BQ176179
      Consensus CDS
      CCDS24635.1
      UniProtKB/Swiss-Prot
      Q8BIJ7
      Related
      ENSMUSP00000020643.4, ENSMUST00000020643.4
      Conserved Domains (3) summary
      cd15758
      Location:638708
      FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
      pfam02759
      Location:151274
      RUN; RUN domain
      cl02073
      Location:444589
      DUF3422; Protein of unknown function (DUF3422)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50280113..50322101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532841.5XP_006532904.1  RUN and FYVE domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:237540
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15758
      Location:545615
      FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
      pfam02759
      Location:58179
      RUN; RUN domain
    2. XM_017314442.2XP_017169931.1  RUN and FYVE domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02759
      Location:151272
      RUN; RUN domain

    RNA

    1. XR_001779949.2 RNA Sequence

    2. XR_004936914.1 RNA Sequence

    3. XR_004936913.1 RNA Sequence

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