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    Prdx2 peroxiredoxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 21672, updated on 16-Aug-2021

    Summary

    Official Symbol
    Prdx2provided by MGI
    Official Full Name
    peroxiredoxin 2provided by MGI
    Primary source
    MGI:MGI:109486
    See related
    Ensembl:ENSMUSG00000005161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; T; TP; TR; PRP; TPx; TSA; TDX1; Tdpx; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8; AL022839
    Expression
    Broad expression in liver E14 (RPKM 507.8), liver E14.5 (RPKM 504.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Prdx2 in Genome Data Viewer
    Location:
    8 C3; 8 41.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85696251..85701440)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84969622..84974811)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87493547..87498212)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene retbindin Neighboring gene ribonuclease H2, large subunit Neighboring gene jun B proto-oncogene Neighboring gene hook microtubule tethering protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables selenium binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thioredoxin peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioredoxin peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables thioredoxin peroxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within respiratory burst involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    peroxiredoxin-2
    Names
    Calpromotin
    Prx II-1
    Trx dependent peroxide reductase 1
    protector protein
    thiol-specific antioxidant protein
    thioredoxin peroxidase 1
    thioredoxin reductase
    thioredoxin-dependent peroxide reductase 1
    thioredoxin-dependent peroxiredoxin 2
    NP_001304314.1
    NP_035693.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317385.1NP_001304314.1  peroxiredoxin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC163703, AK005225, BC086783, CX238307, DV051712
      Consensus CDS
      CCDS40416.1
      UniProtKB/Swiss-Prot
      Q61171
      UniProtKB/TrEMBL
      Q5M9N9
      Related
      ENSMUSP00000105356.2, ENSMUST00000109734.8
      Conserved Domains (2) summary
      PTZ00253
      Location:1195
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:8179
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    2. NM_011563.6NP_035693.3  peroxiredoxin-2

      See identical proteins and their annotated locations for NP_035693.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK005225, AK008433, CD773819
      Consensus CDS
      CCDS40416.1
      UniProtKB/Swiss-Prot
      Q61171
      Related
      ENSMUSP00000005292.9, ENSMUST00000005292.15
      Conserved Domains (2) summary
      PTZ00253
      Location:1195
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:8179
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85696251..85701440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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