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    Eea1 early endosome antigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 216238, updated on 23-Jun-2021

    Summary

    Official Symbol
    Eea1provided by MGI
    Official Full Name
    early endosome antigen 1provided by MGI
    Primary source
    MGI:MGI:2442192
    See related
    Ensembl:ENSMUSG00000036499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZFYVE; ZFYVE2; A430109M19Rik; B230358H09Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.5), placenta adult (RPKM 5.0) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Eea1 in Genome Data Viewer
    Location:
    10; 10 C2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95776525..95881380)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95940663..96045518)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (95403297..95508152)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33377 Neighboring gene predicted gene, 33543 Neighboring gene predicted gene, 24433 Neighboring gene predicted gene, 49817 Neighboring gene predicted gene, 48425

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axonal spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine-pyruvate aminotransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001932.3NP_001001932.1  early endosome antigen 1

      See identical proteins and their annotated locations for NP_001001932.1

      Status: VALIDATED

      Source sequence(s)
      AC115970, BB638838, BC075637
      Consensus CDS
      CCDS36042.1
      UniProtKB/Swiss-Prot
      Q8BL66
      Related
      ENSMUSP00000061493.7, ENSMUST00000053484.8
      Conserved Domains (3) summary
      cd15730
      Location:13471409
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
      pfam01576
      Location:1071119
      Myosin_tail_1; Myosin tail
      pfam07851
      Location:909988
      TMPIT; TMPIT-like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      95776525..95881380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513522.5XP_006513585.1  early endosome antigen 1 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:5041346
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:130794
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:13941456
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    2. XM_006513523.5XP_006513586.1  early endosome antigen 1 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:4991341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:130789
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:13891451
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    3. XM_006513524.5XP_006513587.1  early endosome antigen 1 isoform X3

      Conserved Domains (3) summary
      COG1196
      Location:4621304
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:88752
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:13521414
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
    4. XM_006513525.5XP_006513588.1  early endosome antigen 1 isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:3421184
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:19622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:12321294
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
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