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    Cdc34 cell division cycle 34 [ Mus musculus (house mouse) ]

    Gene ID: 216150, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc34provided by MGI
    Official Full Name
    cell division cycle 34provided by MGI
    Primary source
    MGI:MGI:102657
    See related
    Ensembl:ENSMUSG00000020307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBE2R1; AI327276; E2-CDC34
    Expression
    Ubiquitous expression in testis adult (RPKM 167.9), placenta adult (RPKM 79.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdc34 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (79682194..79688398)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79144940..79151143)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene basigin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 R1
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme R1
    E2 ubiquitin-conjugating enzyme R1
    cell division cycle 34 homolog
    ubiquitin-conjugating enzyme Cdc34
    ubiquitin-conjugating enzyme E2-32 kDa complementing
    ubiquitin-conjugating enzyme E2-CDC34
    ubiquitin-protein ligase R1
    NP_808281.1
    XP_006513545.1
    XP_006513546.1
    XP_017169376.1
    XP_017169377.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359817.1NP_001346746.1  ubiquitin-conjugating enzyme E2 R1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151828, BE988402, BY083281, BY114161, CA320111
      Conserved Domains (1) summary
      cd00195
      Location:11125
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001359818.1NP_001346747.1  ubiquitin-conjugating enzyme E2 R1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151828, BE988402, BY114161, CA320111, CX210748
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_177613.2NP_808281.1  ubiquitin-conjugating enzyme E2 R1 isoform 1

      See identical proteins and their annotated locations for NP_808281.1

      Status: VALIDATED

      Source sequence(s)
      BC039160
      Consensus CDS
      CCDS23983.1
      UniProtKB/Swiss-Prot
      Q8CFI2
      Related
      ENSMUSP00000020550.5, ENSMUST00000020550.12
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      79682194..79688398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313888.1XP_017169377.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CFI2
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_017313887.1XP_017169376.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CFI2
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. XM_006513483.2XP_006513546.1  ubiquitin-conjugating enzyme E2 R1 isoform X3

      Related
      ENSMUSP00000152000.1, ENSMUST00000218964.1
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    4. XM_006513482.2XP_006513545.1  ubiquitin-conjugating enzyme E2 R1 isoform X2

      UniProtKB/TrEMBL
      A0A1W2P7U1
      Related
      ENSMUSP00000151763.1, ENSMUST00000219791.1
      Conserved Domains (1) summary
      cd00195
      Location:11125
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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