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    Micu1 mitochondrial calcium uptake 1 [ Mus musculus (house mouse) ]

    Gene ID: 216001, updated on 31-Jan-2019

    Summary

    Official Symbol
    Micu1provided by MGI
    Official Full Name
    mitochondrial calcium uptake 1provided by MGI
    Primary source
    MGI:MGI:2384909
    See related
    Ensembl:ENSMUSG00000020111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Calc; Cbara1; C730016L05Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 46.0), duodenum adult (RPKM 43.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Micu1 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (59702482..59864134)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59165383..59326871)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uniporter Neighboring gene predicted gene, 40671 Neighboring gene predicted gene, 40672 Neighboring gene predicted gene 17059 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 7413 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 Neighboring gene predicted gene, 46226

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29229, MGC36365, MGC36503, MGC36634

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    uniplex complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium uptake protein 1, mitochondrial
    Names
    calcium binding atopy-related autoantigen 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291442.1NP_001278371.1  calcium uptake protein 1, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001278371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC155827, AC155939, AK046049
      Consensus CDS
      CCDS78817.1
      UniProtKB/Swiss-Prot
      Q8VCX5
      Related
      ENSMUSP00000020311.6, ENSMUST00000020311.12
      Conserved Domains (1) summary
      pfam13202
      Location:231254
      EF-hand_5; EF hand
    2. NM_001291443.1NP_001278372.1  calcium uptake protein 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001278372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC155827, AC155939, BC023022
      Consensus CDS
      CCDS78818.1
      UniProtKB/Swiss-Prot
      Q8VCX5
      Related
      ENSMUSP00000090166.5, ENSMUST00000092508.11
      Conserved Domains (1) summary
      pfam13202
      Location:229252
      EF-hand_5; EF hand
    3. NM_001359267.1NP_001346196.1  calcium uptake protein 1, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC155827, AC155939, AK050113, CX240738
      Conserved Domains (1) summary
      cd16173
      Location:226445
      EFh_MICU1; EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins
    4. NM_144822.3NP_659071.1  calcium uptake protein 1, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_659071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC155827, AC155939, AK050113
      Consensus CDS
      CCDS35909.1
      UniProtKB/Swiss-Prot
      Q8VCX5
      Related
      ENSMUSP00000126597.1, ENSMUST00000165563.7
      Conserved Domains (1) summary
      pfam13202
      Location:225248
      EF-hand_5; EF hand

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      59702482..59864134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513471.2XP_006513534.1  calcium uptake protein 1, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd16173
      Location:226445
      EFh_MICU1; EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins
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