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    Mcu mitochondrial calcium uniporter [ Mus musculus (house mouse) ]

    Gene ID: 215999, updated on 9-Aug-2021

    Summary

    Official Symbol
    Mcuprovided by MGI
    Official Full Name
    mitochondrial calcium uniporterprovided by MGI
    Primary source
    MGI:MGI:3026965
    See related
    Ensembl:ENSMUSG00000009647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm64; Ccdc109; AV064928; C10orf42; Ccdc109a; 2010012O16Rik; D130073L02Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 29.1), bladder adult (RPKM 21.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mcu in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59282806..59453231, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59446984..59617409, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (58911181..59079440, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group XIIB Neighboring gene oncoprotein induced transcript 3 Neighboring gene predicted gene, 36318 Neighboring gene predicted gene, 40671 Neighboring gene predicted gene 10322 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene predicted gene, 40672

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables uniporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables uniporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of uniplex complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium uniporter protein, mitochondrial
    Names
    coiled-coil domain containing 109A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033259.4NP_001028431.2  calcium uniporter protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001028431.2

      Status: VALIDATED

      Source sequence(s)
      AC022699, AK144727, AK161322
      Consensus CDS
      CCDS23866.2
      UniProtKB/Swiss-Prot
      Q3UMR5
      Related
      ENSMUSP00000020312.7, ENSMUST00000020312.13
      Conserved Domains (1) summary
      pfam04678
      Location:116319
      MCU; Mitochondrial calcium uniporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      59282806..59453231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245012.1XP_030100872.1  calcium uniporter protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam04678
      Location:77279
      MCU; Mitochondrial calcium uniporter
    2. XM_006513468.2XP_006513531.1  calcium uniporter protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam04678
      Location:77279
      MCU; Mitochondrial calcium uniporter
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