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    Mcu mitochondrial calcium uniporter [ Mus musculus (house mouse) ]

    Gene ID: 215999, updated on 12-Mar-2019

    Summary

    Official Symbol
    Mcuprovided by MGI
    Official Full Name
    mitochondrial calcium uniporterprovided by MGI
    Primary source
    MGI:MGI:3026965
    See related
    Ensembl:ENSMUSG00000009647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm64; AV064928; C10orf42; Ccdc109a; 2010012O16Rik; D130073L02Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 29.1), bladder adult (RPKM 21.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mcu in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (59446984..59616692, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (58911181..59079440, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group XIIB Neighboring gene oncoprotein induced transcript 3 Neighboring gene predicted gene, 36318 Neighboring gene predicted gene, 40671 Neighboring gene predicted gene, 40672 Neighboring gene mitochondrial calcium uptake 1 Neighboring gene predicted gene 17059

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    uniporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    uniporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    uniplex complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium uniporter protein, mitochondrial
    Names
    coiled-coil domain containing 109A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033259.4NP_001028431.2  calcium uniporter protein, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001028431.2

      Status: VALIDATED

      Source sequence(s)
      AC022699, AK144727, AK161322
      Consensus CDS
      CCDS23866.2
      UniProtKB/Swiss-Prot
      Q3UMR5
      Related
      ENSMUSP00000020312.6, ENSMUST00000020312.12
      Conserved Domains (1) summary
      pfam04678
      Location:116319
      MCU; Mitochondrial calcium uniporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      59446984..59616692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513468.1XP_006513531.1  calcium uniporter protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam04678
      Location:76279
      MCU; Mitochondrial calcium uniporter
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