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    Arrdc1 arrestin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 215705, updated on 23-Jun-2021

    Summary

    Official Symbol
    Arrdc1provided by MGI
    Official Full Name
    arrestin domain containing 1provided by MGI
    Primary source
    MGI:MGI:2446136
    See related
    Ensembl:ENSMUSG00000026972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI957342; BC004091
    Expression
    Broad expression in stomach adult (RPKM 119.7), colon adult (RPKM 105.8) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arrdc1 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24815364..24825347, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24925352..24935335, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (24780872..24790801, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene zinc finger, MYND domain containing 19 Neighboring gene diphthamine biosynethesis 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28029

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular vesicle biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    arrestin domain-containing protein 1
    Names
    alpha-arrestin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162485.1NP_001155957.1  arrestin domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001155957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL732525
      Consensus CDS
      CCDS50521.1
      UniProtKB/Swiss-Prot
      Q99KN1
      Related
      ENSMUSP00000028349.8, ENSMUST00000028349.14
      Conserved Domains (2) summary
      pfam02752
      Location:162283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. NM_178408.3NP_848495.2  arrestin domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AL732525
      Consensus CDS
      CCDS15741.1
      UniProtKB/Swiss-Prot
      Q99KN1
      Related
      ENSMUSP00000099999.4, ENSMUST00000102935.10
      Conserved Domains (2) summary
      pfam02752
      Location:162282
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. NR_027876.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL732525
      Related
      ENSMUST00000155953.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24815364..24825347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497841.1XP_006497904.1  arrestin domain-containing protein 1 isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:244384
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:117239
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:1894
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. XM_006497839.3XP_006497902.1  arrestin domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:288428
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    3. XM_006497838.3XP_006497901.1  arrestin domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:289429
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:162284
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    4. XM_006497840.5XP_006497903.1  arrestin domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:252392
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:125247
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:14102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    5. XM_030249390.2XP_030105250.1  arrestin domain-containing protein 1 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:252386
      PHA03247; large tegument protein UL36; Provisional
      pfam02752
      Location:125247
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:14102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    6. XM_006497842.3XP_006497905.1  arrestin domain-containing protein 1 isoform X6

      Conserved Domains (2) summary
      smart01017
      Location:34107
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      PHA03247
      Location:112252
      PHA03247; large tegument protein UL36; Provisional
    7. XM_036160423.1XP_036016316.1  arrestin domain-containing protein 1 isoform X7

      Conserved Domains (2) summary
      smart01017
      Location:34107
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      PHA03247
      Location:112246
      PHA03247; large tegument protein UL36; Provisional
    8. XM_030249391.1XP_030105251.1  arrestin domain-containing protein 1 isoform X6

      Conserved Domains (2) summary
      smart01017
      Location:34107
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      PHA03247
      Location:112252
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_003952025.2 RNA Sequence

    2. XR_003952030.2 RNA Sequence

    3. XR_004939481.1 RNA Sequence

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