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    Arrdc1 arrestin domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 215705, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arrdc1provided by MGI
    Official Full Name
    arrestin domain containing 1provided by MGI
    Primary source
    MGI:MGI:2446136
    See related
    Ensembl:ENSMUSG00000026972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI957342; BC004091
    Expression
    Broad expression in stomach adult (RPKM 119.7), colon adult (RPKM 105.8) and 22 other tissues See more
    Orthologs

    Genomic context

    See Arrdc1 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (24925352..24935335, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (24780872..24790801, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene zinc finger, MYND domain containing 19 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene diphthamine biosynethesis 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28029

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    arrestin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding, bridging involved in substrate recognition for ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    extracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular vesicle biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    arrestin domain-containing protein 1
    Names
    alpha-arrestin 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162485.1NP_001155957.1  arrestin domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001155957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL732525
      Consensus CDS
      CCDS50521.1
      UniProtKB/Swiss-Prot
      Q99KN1
      Related
      ENSMUSP00000028349.7, ENSMUST00000028349.13
      Conserved Domains (2) summary
      pfam02752
      Location:162283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. NM_178408.3NP_848495.2  arrestin domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AL732525
      Consensus CDS
      CCDS15741.1
      UniProtKB/Swiss-Prot
      Q99KN1
      Related
      ENSMUSP00000099999.3, ENSMUST00000102935.9
      Conserved Domains (2) summary
      pfam02752
      Location:162282
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RNA

    1. NR_027876.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL732525
      Related
      ENSMUST00000155953.7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      24925352..24935335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497841.1XP_006497904.1  arrestin domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      pfam02752
      Location:117238
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:1894
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    2. XM_006497839.1XP_006497902.1  arrestin domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      pfam02752
      Location:162282
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    3. XM_006497838.1XP_006497901.1  arrestin domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      pfam02752
      Location:162283
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:7139
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    4. XM_006497840.3XP_006497903.1  arrestin domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      pfam02752
      Location:125246
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:42102
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    5. XM_006497842.3XP_006497905.1  arrestin domain-containing protein 1 isoform X5

      Conserved Domains (1) summary
      pfam02752
      Location:29106
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
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