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    Rnpep arginyl aminopeptidase (aminopeptidase B) [ Mus musculus (house mouse) ]

    Gene ID: 215615, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rnpepprovided by MGI
    Official Full Name
    arginyl aminopeptidase (aminopeptidase B)provided by MGI
    Primary source
    MGI:MGI:2384902
    See related
    Ensembl:ENSMUSG00000041926 Vega:OTTMUSG00000021833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in duodenum adult (RPKM 45.6), large intestine adult (RPKM 34.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rnpep in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (135262699..135284423, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (137159276..137180661, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene E74-like factor 3 Neighboring gene myeloma-overexpressed gene 2 protein homolog pseudogene Neighboring gene translocase of inner mitochondrial membrane 17a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29229

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cobalt ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aminopeptidase B
    Names
    AP-B
    arginine aminopeptidase
    cytosol aminopeptidase IV
    NP_001153096.1
    NP_663392.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159624.1NP_001153096.1  aminopeptidase B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-terminus compared to isoform 1.
      Source sequence(s)
      AA271633, AK031138, AK159625, BY735801
      Consensus CDS
      CCDS48373.1
      UniProtKB/Swiss-Prot
      Q8VCT3
      UniProtKB/TrEMBL
      E9PYF1, Q8BMH2
      Related
      ENSMUSP00000073962.7, OTTMUSP00000024451, ENSMUST00000074357.7, OTTMUST00000051811
      Conserved Domains (3) summary
      cd09599
      Location:24445
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:24595
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:465605
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    2. NM_145417.3NP_663392.2  aminopeptidase B isoform 1

      See identical proteins and their annotated locations for NP_663392.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA271633, AK159625, BY735801
      Consensus CDS
      CCDS15317.1
      UniProtKB/Swiss-Prot
      Q8VCT3
      Related
      ENSMUSP00000076564.7, OTTMUSP00000024450, ENSMUST00000077340.13, OTTMUST00000051810
      Conserved Domains (3) summary
      cd09599
      Location:24484
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:24634
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:504644
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      135262699..135284423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_387158.2 RNA Sequence

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