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    Rap1b RAS related protein 1b [ Mus musculus (house mouse) ]

    Gene ID: 215449, updated on 22-Aug-2021

    Summary

    Official Symbol
    Rap1bprovided by MGI
    Official Full Name
    RAS related protein 1bprovided by MGI
    Primary source
    MGI:MGI:894315
    See related
    Ensembl:ENSMUSG00000052681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810443E11Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 61.6), bladder adult (RPKM 57.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rap1b in Genome Data Viewer
    Location:
    10; 10 D2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117650502..117681879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117814597..117845974, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (117251653..117283030, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E3 Neighboring gene nucleoporin 107 Neighboring gene predicted gene, 53637 Neighboring gene predicted gene, 40773 Neighboring gene predicted gene, 32552 Neighboring gene predicted gene, 32605

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Rap protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in cellular response to cAMP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of calcium ion-dependent exocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rap-1b
    Names
    GTP-binding protein smg p21B
    NP_077777.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024457.2NP_077777.1  ras-related protein Rap-1b

      See identical proteins and their annotated locations for NP_077777.1

      Status: VALIDATED

      Source sequence(s)
      AK180095, BU848028, BY369341, CK793274, CO803632
      Consensus CDS
      CCDS24196.1
      UniProtKB/Swiss-Prot
      Q99JI6
      UniProtKB/TrEMBL
      Q52L50
      Related
      ENSMUSP00000066238.8, ENSMUST00000064667.9
      Conserved Domains (1) summary
      cd04175
      Location:3167
      Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      117650502..117681879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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