U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Utp25 UTP25 small subunit processome component [ Mus musculus (house mouse) ]

    Gene ID: 215193, updated on 9-Dec-2024

    Summary

    Official Symbol
    Utp25provided by MGI
    Official Full Name
    UTP25 small subunit processome componentprovided by MGI
    Primary source
    MGI:MGI:2138080
    See related
    Ensembl:ENSMUSG00000016181 AllianceGenome:MGI:2138080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Def; mDef; Diexf
    Summary
    Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Involved in positive regulation of embryonic development. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in cerebral cortex; submandibular gland primordium; tooth; and vibrissa. Orthologous to human UTP25 (UTP25 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.5), limb E14.5 (RPKM 4.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Utp25 in Genome Data Viewer
    Location:
    1 H6; 1 97.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (192786707..192812603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (193104399..193130283, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin XIV Neighboring gene predicted gene, 39746 Neighboring gene predicted gene, 31406 Neighboring gene predicted gene, 39747 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194913524-194913725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194948976-194949260 Neighboring gene STARR-positive B cell enhancer ABC_E3355 Neighboring gene RIKEN cDNA A130010J15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:194995551-194995752 Neighboring gene STARR-positive B cell enhancer ABC_E7790 Neighboring gene interferon regulatory factor 6 Neighboring gene TRAF3 interacting protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables U3 snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    U3 small nucleolar RNA-associated protein 25 homolog
    Names
    UTP25 small subunit processor component
    digestive-organ expansion factor homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368818.2NP_001355747.1  U3 small nucleolar RNA-associated protein 25 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL365322
      UniProtKB/Swiss-Prot
      Q8BTT6, Q8BWJ1, Q8VEC2
      Conserved Domains (1) summary
      pfam06862
      Location:175650
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25
    2. NM_001368819.2NP_001355748.1  U3 small nucleolar RNA-associated protein 25 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL365322
      Conserved Domains (1) summary
      pfam06862
      Location:288510
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25
    3. NM_145415.3NP_663390.2  U3 small nucleolar RNA-associated protein 25 homolog isoform 1

      See identical proteins and their annotated locations for NP_663390.2

      Status: VALIDATED

      Source sequence(s)
      AL365322
      Consensus CDS
      CCDS15631.1
      UniProtKB/Swiss-Prot
      Q8BTT6, Q8BWJ1, Q8VEC2
      UniProtKB/TrEMBL
      A0A0R4J114
      Related
      ENSMUSP00000082691.2, ENSMUST00000085555.7
      Conserved Domains (1) summary
      pfam06862
      Location:288763
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    RNA

    1. NR_151719.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365322
      Related
      ENSMUST00000195291.6
    2. NR_185200.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365322

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      192786707..192812603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252943.2XP_030108803.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8BTT6, Q8BWJ1, Q8VEC2
      Conserved Domains (1) summary
      pfam06862
      Location:175650
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25
    2. XM_006497250.2XP_006497313.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X2

      Conserved Domains (1) summary
      pfam06862
      Location:1466
      UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

    RNA

    1. XR_004941611.1 RNA Sequence