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    Astl astacin-like metalloendopeptidase (M12 family) [ Mus musculus (house mouse) ]

    Gene ID: 215095, updated on 4-Mar-2019

    Summary

    Official Symbol
    Astlprovided by MGI
    Official Full Name
    astacin-like metalloendopeptidase (M12 family)provided by MGI
    Primary source
    MGI:MGI:3046414
    See related
    Ensembl:ENSMUSG00000050468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sas1b; C87576; 7420700F21
    Expression
    Restricted expression toward ovary adult (RPKM 7.3) See more
    Orthologs

    Genomic context

    See Astl in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (127338639..127357655)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (127164375..127183387)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46762 Neighboring gene dual specificity phosphatase 2 Neighboring gene adrenergic receptor, alpha 2b Neighboring gene predicted gene, 39923

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC76457

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aspartic-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamic-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prevention of polyspermy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prevention of polyspermy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cortical granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cortical granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    astacin-like metalloendopeptidase
    Names
    astl
    oocyte astacin
    ovastacin
    sperm acrosomal SLLP1
    sperm acrosomal SLLP1-binding protein
    NP_001277932.1
    NP_766127.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291003.1NP_001277932.1  astacin-like metalloendopeptidase isoform a precursor

      See identical proteins and their annotated locations for NP_001277932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      BC064729, DV649054, DV662582
      Consensus CDS
      CCDS71138.1
      UniProtKB/Swiss-Prot
      Q6HA09
      Related
      ENSMUSP00000087102.3, ENSMUST00000089673.9
      Conserved Domains (2) summary
      pfam01400
      Location:92282
      Astacin; Astacin (Peptidase family M12A)
      cl00064
      Location:100281
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    2. NM_172539.3NP_766127.1  astacin-like metalloendopeptidase isoform b

      See identical proteins and their annotated locations for NP_766127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK033037, AL845368, DV662582
      Consensus CDS
      CCDS16700.1
      UniProtKB/Swiss-Prot
      Q6HA09
      Related
      ENSMUSP00000054456.2, ENSMUST00000059839.8
      Conserved Domains (2) summary
      pfam01400
      Location:71261
      Astacin; Astacin (Peptidase family M12A)
      cl00064
      Location:79260
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      127338639..127357655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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