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    Csnk1g1 casein kinase 1, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 214897, updated on 31-Jan-2019

    Summary

    Official Symbol
    Csnk1g1provided by MGI
    Official Full Name
    casein kinase 1, gamma 1provided by MGI
    Primary source
    MGI:MGI:2660884
    See related
    Ensembl:ENSMUSG00000032384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130020E21Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.9), whole brain E14.5 (RPKM 3.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Csnk1g1 in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (65908962..66045015)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (65756817..65892821)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30314 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene PCNA clamp associated factor Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene sorting nexin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
      Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Hedgehog signaling pathway, conserved biosystem (from KEGG)
      Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase I isoform gamma-1; casein kinase I
    Names
    CKI-gamma 1
    casein kinase I, gamma 1
    NP_775277.2
    XP_006511071.1
    XP_011241005.1
    XP_011241006.1
    XP_011241007.1
    XP_011241008.1
    XP_011241009.1
    XP_011241010.1
    XP_011241011.1
    XP_011241012.1
    XP_011241013.1
    XP_011241014.1
    XP_017168762.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173185.2NP_775277.2  casein kinase I isoform gamma-1

      See identical proteins and their annotated locations for NP_775277.2

      Status: VALIDATED

      Source sequence(s)
      AC112676, AK090262, BC064645
      Consensus CDS
      CCDS23300.1
      UniProtKB/Swiss-Prot
      Q8BTH8
      UniProtKB/TrEMBL
      Q6P2B2
      Related
      ENSMUSP00000034949.3, ENSMUST00000034949.9
      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      65908962..66045015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242704.1XP_011241006.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011241006.1

      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    2. XM_011242703.1XP_011241005.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011241005.1

      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    3. XM_011242708.1XP_011241010.1  casein kinase I isoform X2

      See identical proteins and their annotated locations for XP_011241010.1

      UniProtKB/Swiss-Prot
      Q8BTH8
      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    4. XM_011242709.1XP_011241011.1  casein kinase I isoform X4

      See identical proteins and their annotated locations for XP_011241011.1

      UniProtKB/TrEMBL
      Q6P2B2
      Related
      ENSMUSP00000113160.1, ENSMUST00000117849.2
      Conserved Domains (3) summary
      COG0515
      Location:43266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331381
      CK1gamma_C; Casein kinase 1 gamma C terminal
    5. XM_011242710.1XP_011241012.1  casein kinase I isoform X5

      UniProtKB/TrEMBL
      A0A0U1RNW0
      Related
      ENSMUSP00000145724.1, ENSMUST00000205379.1
      Conserved Domains (3) summary
      COG0515
      Location:43266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331381
      CK1gamma_C; Casein kinase 1 gamma C terminal
    6. XM_017313273.1XP_017168762.1  casein kinase I isoform X3

    7. XM_011242707.1XP_011241009.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011241009.1

      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    8. XM_011242706.1XP_011241008.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011241008.1

      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    9. XM_011242705.1XP_011241007.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_011241007.1

      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    10. XM_006511008.2XP_006511071.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_006511071.1

      Conserved Domains (3) summary
      COG0515
      Location:43396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331418
      CK1gamma_C; Casein kinase 1 gamma C terminal
    11. XM_011242712.1XP_011241014.1  casein kinase I isoform X7

      UniProtKB/TrEMBL
      A0A0U1RPD7
      Related
      ENSMUSP00000145938.1, ENSMUST00000130798.2
      Conserved Domains (3) summary
      COG0515
      Location:43266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331369
      CK1gamma_C; Casein kinase 1 gamma C terminal
    12. XM_011242711.1XP_011241013.1  casein kinase I isoform X6

      Conserved Domains (3) summary
      COG0515
      Location:43266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331369
      CK1gamma_C; Casein kinase 1 gamma C terminal
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