U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tcp1 t-complex protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21454, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tcp1provided by MGI
    Official Full Name
    t-complex protein 1provided by MGI
    Primary source
    MGI:MGI:98535
    See related
    Ensembl:ENSMUSG00000068039 AllianceGenome:MGI:98535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCT; p63; Cct1; Ccta; TRic; Tp63; Tcp-1; c-cpn
    Summary
    Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; toxin transport; and translocation of peptides or proteins into host cell cytoplasm. Located in several cellular components, including acrosomal vesicle; heterochromatin; and pericentriolar material. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including cerebral cortex; extraembryonic component; genitourinary system; humerus; and immune system. Orthologous to human TCP1 (t-complex 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 173.1), CNS E11.5 (RPKM 109.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tcp1 in Genome Data Viewer
    Location:
    17 A1; 17 8.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13135216..13143954)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12916329..12925067)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member H Neighboring gene poly(A)-specific ribonuclease (PARN)-like domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2471 Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene predicted gene, 26130 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene acetyl-Coenzyme A acetyltransferase 3 Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chaperone mediated protein folding independent of cofactor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of protein localization to telomere IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase RNA localization to Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomerase RNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in scaRNA localization to Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in scaRNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 1 subunit alpha
    Names
    CCT-alpha
    T-complex protein 1 subunit alpha A
    T-complex protein 1 subunit alpha B
    TCP-1-A
    TCP-1-B
    TCP-1-alpha
    t-complex polypeptide 1
    tailless complex polypeptide 1A
    tailless complex polypeptide 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290712.1NP_001277641.1  T-complex protein 1 subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_001277641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK149611, AK153430, CN725473
      Consensus CDS
      CCDS70760.1
      UniProtKB/Swiss-Prot
      P11983
      Related
      ENSMUSP00000086418.7, ENSMUST00000089024.13
      Conserved Domains (2) summary
      cd03335
      Location:2486
      TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02340
      Location:2491
      chap_CCT_alpha; T-complex protein 1, alpha subunit
    2. NM_013686.4NP_038714.2  T-complex protein 1 subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_038714.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK149611, AK166966, CN725473
      Consensus CDS
      CCDS28397.1
      UniProtKB/Swiss-Prot
      P11983, P11984, Q3TJ96, Q3TKU1, Q3U5T8, Q3U7I8, Q3UAA8, Q3UB80, Q3UE48
      Related
      ENSMUSP00000116108.2, ENSMUST00000151287.8
      Conserved Domains (2) summary
      cd03335
      Location:9535
      TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02340
      Location:5540
      chap_CCT_alpha; T-complex protein 1, alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      13135216..13143954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)