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    Tcp1 t-complex protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21454, updated on 23-Sep-2018

    Summary

    Official Symbol
    Tcp1provided by MGI
    Official Full Name
    t-complex protein 1provided by MGI
    Primary source
    MGI:MGI:98535
    See related
    Ensembl:ENSMUSG00000068039 Vega:OTTMUSG00000028087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCT; p63; Cct1; Ccta; TRic; Tp63; Tcp-1; c-cpn; AI528772
    Expression
    Ubiquitous expression in testis adult (RPKM 173.1), CNS E11.5 (RPKM 109.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See Tcp1 in Genome Data Viewer
    Location:
    17 A1; 17 8.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (12916329..12925067)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13109331..13117933)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member H Neighboring gene poly(A)-specific ribonuclease (PARN)-like domain containing 1 Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene acetyl-Coenzyme A acetyltransferase 3 Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase RNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    scaRNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translocation of peptides or proteins into host cell cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 1 subunit alpha
    Names
    CCT-alpha
    T-complex protein 1 subunit alpha A
    T-complex protein 1 subunit alpha B
    TCP-1-A
    TCP-1-B
    TCP-1-alpha
    t-complex polypeptide 1
    tailless complex polypeptide 1A
    tailless complex polypeptide 1B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290712.1NP_001277641.1  T-complex protein 1 subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_001277641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK149611, AK153430, CN725473
      Consensus CDS
      CCDS70760.1
      UniProtKB/Swiss-Prot
      P11983
      Related
      ENSMUSP00000086418.6, OTTMUSP00000035356, ENSMUST00000089024.12, OTTMUST00000069573
      Conserved Domains (2) summary
      cd03335
      Location:2486
      TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02340
      Location:2491
      chap_CCT_alpha; T-complex protein 1, alpha subunit
    2. NM_013686.4NP_038714.2  T-complex protein 1 subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_038714.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK149611, AK166966, CN725473
      Consensus CDS
      CCDS28397.1
      UniProtKB/Swiss-Prot
      P11983
      Related
      ENSMUSP00000116108.1, OTTMUSP00000035355, ENSMUST00000151287.7, OTTMUST00000069571
      Conserved Domains (2) summary
      cd03335
      Location:9535
      TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02340
      Location:5540
      chap_CCT_alpha; T-complex protein 1, alpha subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      12916329..12925067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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