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    Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

    Gene ID: 214498, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc73provided by MGI
    Official Full Name
    cell division cycle 73, Paf1/RNA polymerase II complex componentprovided by MGI
    Primary source
    MGI:MGI:2384876
    See related
    Ensembl:ENSMUSG00000026361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrpt2; C81219; 8430414L16Rik; C130030P16Rik
    Expression
    Broad expression in placenta adult (RPKM 8.5), CNS E11.5 (RPKM 3.0) and 19 other tissues See more
    Orthologs

    Genomic context

    See Cdc73 in Genome Data Viewer
    Location:
    1 F; 1 62.52 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (143603276..143702893, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (145454629..145549814, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35244 Neighboring gene predicted gene, 35303 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29274, MGC36559

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H2B ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription elongation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    parafibromin
    Names
    cell division cycle protein 73 homolog
    hyperparathyroidism 2 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145991.2NP_666103.1  parafibromin

      See identical proteins and their annotated locations for NP_666103.1

      Status: VALIDATED

      Source sequence(s)
      AK048027, AK080861, AK134896, AK153645, AL592403, BB645172
      Consensus CDS
      CCDS15341.1
      UniProtKB/Swiss-Prot
      Q8JZM7
      UniProtKB/TrEMBL
      Q3U5E6
      Related
      ENSMUSP00000018337.7, ENSMUST00000018337.8
      Conserved Domains (2) summary
      pfam05179
      Location:357520
      CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
      pfam16050
      Location:1297
      CDC73_N; Paf1 complex subunit CDC73 N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      143603276..143702893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529366.3XP_006529429.1  parafibromin isoform X2

      Conserved Domains (1) summary
      pfam16050
      Location:1297
      CDC73_N; Paf1 complex subunit CDC73 N-terminal
    2. XM_006529365.1XP_006529428.1  parafibromin isoform X1

      Conserved Domains (1) summary
      pfam16050
      Location:1297
      CDC73_N; Paf1 complex subunit CDC73 N-terminal
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