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    Fam168b family with sequence similarity 168, member B [ Mus musculus (house mouse) ]

    Gene ID: 214469, updated on 26-Sep-2022

    Summary

    Official Symbol
    Fam168bprovided by MGI
    Official Full Name
    family with sequence similarity 168, member Bprovided by MGI
    Primary source
    MGI:MGI:2448487
    See related
    Ensembl:ENSMUSG00000037503 AllianceGenome:MGI:2448487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mani; mKIAA4042
    Summary
    Predicted to be located in cell projection; cytoplasm; and plasma membrane. Predicted to be integral component of membrane. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FAM168B (family with sequence similarity 168 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 73.1), thymus adult (RPKM 71.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fam168b in Genome Data Viewer
    Location:
    1; 1 B
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34852299..34882141, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34813218..34843050, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 4 Neighboring gene alpha-endosulfine pseudogene Neighboring gene predicted gene, 32790 Neighboring gene pleckstrin homology domain containing, family B (evectins) member 2 Neighboring gene uncharacterized protein C19orf29 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4042, MGC58017

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myelin-associated neurite-outgrowth inhibitor
    Names
    protein FAM168B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160235.2NP_001153707.1  myelin-associated neurite-outgrowth inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001153707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site around the middle of the CDS compared to variant 4. It encodes isoform 1, which is shorter than isoform 4.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS48236.1
      UniProtKB/Swiss-Prot
      Q80XQ8
      UniProtKB/TrEMBL
      A0A6P7QPT0, A0A8C6HD91, G3UWF0
      Related
      ENSMUSP00000131720.2, ENSMUST00000167518.8
      Conserved Domains (1) summary
      pfam14944
      Location:1206
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    2. NM_001160236.2NP_001153708.1  myelin-associated neurite-outgrowth inhibitor isoform 2

      See identical proteins and their annotated locations for NP_001153708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' CDS compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS48235.1
      UniProtKB/Swiss-Prot
      Q80XQ8
      UniProtKB/TrEMBL
      A0A6P5QGE1, E9Q917
      Related
      ENSMUSP00000128676.2, ENSMUST00000170092.8
      Conserved Domains (1) summary
      pfam14944
      Location:1201
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    3. NM_001403152.1NP_001390081.1  myelin-associated neurite-outgrowth inhibitor isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC107738
      UniProtKB/TrEMBL
      A0A6P7R2E9
    4. NM_174997.3NP_778162.1  myelin-associated neurite-outgrowth inhibitor isoform 3

      See identical proteins and their annotated locations for NP_778162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' CDS and uses an alternate splice site near the central region of the CDS, compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS14873.1
      UniProtKB/Swiss-Prot
      Q5DTR7, Q80XQ8
      UniProtKB/TrEMBL
      A0A6P5QPT0, A0A8C6HCM9
      Related
      ENSMUSP00000042212.6, ENSMUST00000047534.12
      Conserved Domains (1) summary
      pfam14944
      Location:1194
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34852299..34882141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495845.3XP_006495908.1  myelin-associated neurite-outgrowth inhibitor isoform X1

      Conserved Domains (1) summary
      pfam14944
      Location:1213
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1