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    Cdk5rap2 CDK5 regulatory subunit associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 214444, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk5rap2provided by MGI
    Official Full Name
    CDK5 regulatory subunit associated protein 2provided by MGI
    Primary source
    MGI:MGI:2384875
    See related
    Ensembl:ENSMUSG00000039298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    an; mKIAA1633; 2900018K03Rik
    Expression
    Broad expression in testis adult (RPKM 11.0), CNS E11.5 (RPKM 5.7) and 23 other tissues See more
    Orthologs

    Genomic context

    See Cdk5rap2 in Genome Data Viewer
    Location:
    4; 4 C2
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (70216855..70410435, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (69884058..70071401, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit C pseudogene Neighboring gene 3-hydroxyisobutyrate dehydrogenase pseudogene Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 3 Neighboring gene multiple EGF-like-domains 9 Neighboring gene predicted gene, 32209

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hertwig's anemia
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 
    • Radiation induced (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38528

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CDK5 regulatory subunit-associated protein 2
    Names
    CDK5 activator-binding protein C48

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313762.1NP_001300691.1  CDK5 regulatory subunit-associated protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three exons in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL929409, BC079888, CF738512
      Conserved Domains (1) summary
      cl21524
      Location:11651287
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
    2. NM_145990.4NP_666102.2  CDK5 regulatory subunit-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_666102.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL929409, BC086696, CF738512, CN698992
      Consensus CDS
      CCDS38779.1
      UniProtKB/Swiss-Prot
      Q8K389
      UniProtKB/TrEMBL
      Q0VGR5
      Related
      ENSMUSP00000119891.1, ENSMUST00000144099.7
      Conserved Domains (3) summary
      cl21524
      Location:14381560
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
      pfam00769
      Location:146401
      ERM; Ezrin/radixin/moesin family
      pfam07989
      Location:60128
      Cnn_1N; Centrosomin N-terminal motif 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      70216855..70410435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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