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    Tfcp2 transcription factor CP2 [ Mus musculus (house mouse) ]

    Gene ID: 21422, updated on 2-Oct-2018

    Summary

    Official Symbol
    Tfcp2provided by MGI
    Official Full Name
    transcription factor CP2provided by MGI
    Primary source
    MGI:MGI:98509
    See related
    Ensembl:ENSMUSG00000009733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CP2; LSF; CP-2; LBP1; UBP-1; LBP-1c; LBP-1d; Tcfcp2; D230015P20Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 6.2), CNS E11.5 (RPKM 6.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tfcp2 in Genome Data Viewer
    Location:
    15 F1; 15 56.33 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (100497202..100552014, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (100333227..100382378, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene POU domain, class 6, transcription factor 1 Neighboring gene RIKEN cDNA C330013E15 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-globin transcription factor CP2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289603.1NP_001276532.1  alpha-globin transcription factor CP2 isoform 2

      See identical proteins and their annotated locations for NP_001276532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC123724, AC139571
      UniProtKB/Swiss-Prot
      Q9ERA0
      Related
      ENSMUSP00000009877.7, ENSMUST00000009877.7
      Conserved Domains (2) summary
      pfam04516
      Location:52257
      CP2; CP2 transcription factor
      cl15755
      Location:329393
      SAM_superfamily; SAM (Sterile alpha motif )
    2. NM_001355497.1NP_001342426.1  alpha-globin transcription factor CP2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724, AC139571
      Conserved Domains (2) summary
      cd09589
      Location:329395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52257
      CP2; CP2 transcription factor
    3. NM_033476.3NP_258437.1  alpha-globin transcription factor CP2 isoform 1

      See identical proteins and their annotated locations for NP_258437.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139571, AK146503
      Consensus CDS
      CCDS27840.1
      UniProtKB/Swiss-Prot
      Q9ERA0
      Related
      ENSMUSP00000155683.1, ENSMUST00000229696.1
      Conserved Domains (2) summary
      cd09589
      Location:329395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52257
      CP2; CP2 transcription factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      100497202..100552014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316538.1XP_017172027.1  alpha-globin transcription factor CP2 isoform X2

    2. XM_017316537.1XP_017172026.1  alpha-globin transcription factor CP2 isoform X1

    3. XM_017316539.1XP_017172028.1  alpha-globin transcription factor CP2 isoform X1

    4. XM_017316541.1XP_017172030.1  alpha-globin transcription factor CP2 isoform X4

    5. XM_017316542.1XP_017172031.1  alpha-globin transcription factor CP2 isoform X5

    6. XM_006520738.2XP_006520801.2  alpha-globin transcription factor CP2 isoform X3

      Conserved Domains (2) summary
      cd09589
      Location:329395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52257
      CP2; CP2 transcription factor
    7. XM_017316540.1XP_017172029.1  alpha-globin transcription factor CP2 isoform X3

      Related
      ENSMUSP00000155581.1, ENSMUST00000229581.1
      Conserved Domains (2) summary
      cd09589
      Location:329395
      SAM_TFCP2; SAM domain of TFCP2 transcription factors
      pfam04516
      Location:52257
      CP2; CP2 transcription factor
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