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    Ago3 argonaute RISC catalytic subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 214150, updated on 8-Feb-2024

    Summary

    Official Symbol
    Ago3provided by MGI
    Official Full Name
    argonaute RISC catalytic subunit 3provided by MGI
    Primary source
    MGI:MGI:2446634
    See related
    Ensembl:ENSMUSG00000028842 AllianceGenome:MGI:2446634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif2c3; C130014L07Rik
    Summary
    Enables RNA binding activity. Involved in positive regulation of NIK/NF-kappaB signaling and positive regulation of gene expression. Located in condensed nuclear chromosome. Part of RISC complex. Is expressed in several structures, including central nervous system; early embryo; lung mesenchyme; sensory organ; and tooth. Orthologous to human AGO3 (argonaute RISC catalytic component 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 2.8), frontal lobe adult (RPKM 2.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ago3 in Genome Data Viewer
    Location:
    4 D2.2; 4 60.39 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126220797..126323360, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126326994..126431670, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125998967-125999150 Neighboring gene ADP-ribosylserine hydrolase Neighboring gene STARR-seq mESC enhancer starr_11400 Neighboring gene tektin 2 Neighboring gene STARR-seq mESC enhancer starr_11401 Neighboring gene STARR-positive B cell enhancer ABC_E7988 Neighboring gene argonaute RISC catalytic subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11403 Neighboring gene STARR-positive B cell enhancer ABC_E2714 Neighboring gene STARR-seq mESC enhancer starr_11404 Neighboring gene argonaute RISC catalytic subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endoribonuclease activity, cleaving miRNA-paired mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein argonaute-3
    Names
    Piwi/Argonaute family protein meIF2C3
    argonaute 3
    argonaute RISC catalytic component 3
    argonaute3
    eIF-2C 3
    eIF2C 3
    eukaryotic translation initiation factor 2C, 3
    mAgo3
    NP_700451.2
    XP_006502980.1
    XP_011238780.1
    XP_017175589.1
    XP_030109249.1
    XP_030109250.1
    XP_030109251.1
    XP_036019842.1
    XP_036019844.1
    XP_036019845.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153402.2NP_700451.2  protein argonaute-3

      See identical proteins and their annotated locations for NP_700451.2

      Status: VALIDATED

      Source sequence(s)
      AK083652, AL606976, BY235425
      Consensus CDS
      CCDS18652.1
      UniProtKB/Swiss-Prot
      Q3TBP7, Q8CJF9
      UniProtKB/TrEMBL
      Q7M738
      Related
      ENSMUSP00000066633.7, ENSMUST00000069097.13
      Conserved Domains (5) summary
      PLN03202
      Location:20859
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:228348
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:393818
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:178227
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:20167
      ArgoN; N-terminal domain of argonaute

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      126220797..126323360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502917.5XP_006502980.1  protein argonaute-3 isoform X2

      UniProtKB/TrEMBL
      Q7M738
      Conserved Domains (4) summary
      cd02846
      Location:228348
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:393818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:177227
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:73167
      ArgoN; N-terminal domain of argonaute
    2. XM_011240478.4XP_011238780.1  protein argonaute-3 isoform X1

      UniProtKB/TrEMBL
      Q7M738
      Conserved Domains (4) summary
      cd02846
      Location:228348
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:393818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:177227
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:73167
      ArgoN; N-terminal domain of argonaute
    3. XM_036163952.1XP_036019845.1  protein argonaute-3 isoform X3

      Conserved Domains (2) summary
      cd02846
      Location:1114
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:159584
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    4. XM_030253390.2XP_030109250.1  protein argonaute-3 isoform X4

      Conserved Domains (2) summary
      cd04657
      Location:118543
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam02170
      Location:190
      PAZ; PAZ domain
    5. XM_030253389.2XP_030109249.1  protein argonaute-3 isoform X4

      Conserved Domains (2) summary
      cd04657
      Location:118543
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam02170
      Location:190
      PAZ; PAZ domain
    6. XM_036163949.1XP_036019842.1  protein argonaute-3 isoform X3

      Conserved Domains (2) summary
      cd02846
      Location:1114
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:159584
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    7. XM_030253391.2XP_030109251.1  protein argonaute-3 isoform X4

      Conserved Domains (2) summary
      cd04657
      Location:118543
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam02170
      Location:190
      PAZ; PAZ domain
    8. XM_036163951.1XP_036019844.1  protein argonaute-3 isoform X3

      Conserved Domains (2) summary
      cd02846
      Location:1114
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:159584
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
    9. XM_017320100.2XP_017175589.1  protein argonaute-3 isoform X4

      Conserved Domains (2) summary
      cd04657
      Location:118543
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam02170
      Location:190
      PAZ; PAZ domain

    RNA

    1. XR_001784115.3 RNA Sequence