U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Larp1b La ribonucleoprotein 1B [ Mus musculus (house mouse) ]

    Gene ID: 214048, updated on 26-Sep-2022

    Summary

    Official Symbol
    Larp1bprovided by MGI
    Official Full Name
    La ribonucleoprotein 1Bprovided by MGI
    Primary source
    MGI:MGI:1914604
    See related
    Ensembl:ENSMUSG00000025762 AllianceGenome:MGI:1914604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Larp2; 1700108L22Rik; 4933421B21Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of translation. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP1B (La ribonucleoprotein 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 7.9), small intestine adult (RPKM 2.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Larp1b in Genome Data Viewer
    Location:
    3; 3 B
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (40904198..40994642)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (40949770..41040207)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430590A07 gene Neighboring gene abhydrolase domain containing 18 Neighboring gene FUN14 domain containing 2B Neighboring gene predicted gene, 22043 Neighboring gene predicted gene 42437 Neighboring gene progesterone receptor membrane component 2 Neighboring gene predicted gene, 40038

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10378, MGC38253, MGC117760

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    la-related protein 1B
    Names
    La ribonucleoprotein domain family, member 1B
    La ribonucleoprotein domain family, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040399.3NP_001035489.2  la-related protein 1B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102794
      UniProtKB/TrEMBL
      F6U5V1
      Related
      ENSMUSP00000141487.2, ENSMUST00000191805.7
      Conserved Domains (1) summary
      cd08038
      Location:422494
      LARP_2; La RNA-binding domain of La-related protein 2
    2. NM_001368221.1NP_001355150.1  la-related protein 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102794
      Consensus CDS
      CCDS38423.1
      UniProtKB/TrEMBL
      A0A0A6YWC2
      Conserved Domains (1) summary
      cd08038
      Location:216288
      LARP_2; La RNA-binding domain of La-related protein 2
    3. NM_001368222.1NP_001355151.1  la-related protein 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102794
      Consensus CDS
      CCDS89623.1
      UniProtKB/TrEMBL
      Q3TQS1
      Related
      ENSMUSP00000142106.2, ENSMUST00000191872.6
    4. NM_001394999.1NP_001381928.1  la-related protein 1B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102794
      UniProtKB/TrEMBL
      A0A0A6YWC2
      Conserved Domains (1) summary
      cd08038
      Location:216288
      LARP_2; La RNA-binding domain of La-related protein 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      40904198..40994642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163009.1XP_036018902.1  la-related protein 1B isoform X3

    2. XM_036163004.1XP_036018897.1  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422494
      LARP_2; La RNA-binding domain of La-related protein 2
    3. XM_036163005.1XP_036018898.1  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Related
      ENSMUSP00000037127.8, ENSMUST00000048490.13
      Conserved Domains (1) summary
      cd08038
      Location:422494
      LARP_2; La RNA-binding domain of La-related protein 2
    4. XM_030252544.2XP_030108404.2  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422494
      LARP_2; La RNA-binding domain of La-related protein 2
    5. XM_036163006.1XP_036018899.1  la-related protein 1B isoform X1

      UniProtKB/TrEMBL
      F6U5V1
      Conserved Domains (1) summary
      cd08038
      Location:422494
      LARP_2; La RNA-binding domain of La-related protein 2
    6. XM_036163008.1XP_036018901.1  la-related protein 1B isoform X2

      UniProtKB/TrEMBL
      A0A0A6YWC2
      Conserved Domains (1) summary
      cd08038
      Location:216288
      LARP_2; La RNA-binding domain of La-related protein 2
    7. XM_036163007.1XP_036018900.1  la-related protein 1B isoform X2

      UniProtKB/TrEMBL
      A0A0A6YWC2
      Conserved Domains (1) summary
      cd08038
      Location:216288
      LARP_2; La RNA-binding domain of La-related protein 2
    8. XM_036163010.1XP_036018903.1  la-related protein 1B isoform X4

      Conserved Domains (1) summary
      smart00684
      Location:119157
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    9. XM_036163011.1XP_036018904.1  la-related protein 1B isoform X5

      Related
      ENSMUSP00000096721.4, ENSMUST00000099121.10
      Conserved Domains (1) summary
      smart00684
      Location:119157
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027663.1: Suppressed sequence

      Description
      NM_027663.1: This RefSeq was suppressed temporarily because it represents a fragment of an Larp2 mRNA.
    2. NM_145988.1: Suppressed sequence

      Description
      NM_145988.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.