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    Skp1 S-phase kinase-associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21402, updated on 16-Oct-2021

    Summary

    Official Symbol
    Skp1provided by MGI
    Official Full Name
    S-phase kinase-associated protein 1provided by MGI
    Primary source
    MGI:MGI:103575
    See related
    Ensembl:ENSMUSG00000036309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OCP2; p19A; 15kDa; EMC19; Skp1a; OCP-II; Tceb1l; p19Skp1; 2610043E24Rik; 2610206H23Rik
    Expression
    Broad expression in CNS E18 (RPKM 68.9), CNS E11.5 (RPKM 64.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Skp1 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52121349..52137685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52230522..52246858)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (52045497..52060360)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12206 Neighboring gene olfactory receptor 1371 Neighboring gene transcription factor 7, T cell specific Neighboring gene predicted gene, 30217 Neighboring gene voltage-dependent anion channel 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables F-box domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul7-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul7-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    S-phase kinase-associated protein 1
    Names
    S-phase kinase-associated protein 1A
    cyclin-A/CDK2-associated protein p19
    NP_035673.3
    XP_006532849.1
    XP_036012398.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011543.4NP_035673.3  S-phase kinase-associated protein 1

      See identical proteins and their annotated locations for NP_035673.3

      Status: VALIDATED

      Source sequence(s)
      AK012498, AK078330, BU841654
      Consensus CDS
      CCDS24669.1
      UniProtKB/Swiss-Prot
      Q9WTX5
      UniProtKB/TrEMBL
      Q5SUR3
      Related
      ENSMUSP00000038744.6, ENSMUST00000037324.12
      Conserved Domains (2) summary
      cd18322
      Location:3127
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:113160
      Skp1; Skp1 family, dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      52121349..52137685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532786.2XP_006532849.1  S-phase kinase-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006532849.1

      UniProtKB/Swiss-Prot
      Q9WTX5
      UniProtKB/TrEMBL
      Q5SUR3
      Conserved Domains (2) summary
      cd18322
      Location:3127
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:113160
      Skp1; Skp1 family, dimerization domain
    2. XM_036156505.1XP_036012398.1  S-phase kinase-associated protein 1 isoform X2

      Conserved Domains (2) summary
      cd18322
      Location:292
      BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins
      pfam01466
      Location:78125
      Skp1; Skp1 family, dimerization domain
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